Simultaneous transrectal ultrasound and photoacoustic human prostate imaging

Sri Rajasekhar Kothapalli, Geoffrey A. Sonn, Jung Woo Choe, Amin Nikoozadeh, Anshuman Bhuyan, Kwan Kyu Park, Paul Cristman, Richard Fan, Azadeh Moini, Byung Chul Lee, Jonathan Wu, Thomas E. Carver, Dharati Trivedi, Lillian Shiiba, Idan Steinberg, David M. Huland, Morten F. Rasmussen, Joseph C. Liao, James D. Brooks, Pierre T. Khuri-YakubSanjiv S. Gambhir

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Imaging technologies that simultaneously provide anatomical, functional, and molecular information are emerging as an attractive choice for disease screening and management. Since the 1980s, transrectal ultrasound (TRUS) has been routinely used to visualize prostatic anatomy and guide needle biopsy, despite limited specificity. Photoacoustic imaging (PAI) provides functional and molecular information at ultrasonic resolution based on optical absorption. Combining the strengths of TRUS and PAI approaches, we report the development and bench-to-bedside translation of an integrated TRUS and photoacoustic (TRUSPA) device. TRUSPA uses a miniaturized capacitive micromachined ultrasonic transducer array for simultaneous imaging of anatomical and molecular optical contrasts [intrinsic: hemoglobin; extrinsic: intravenous indocyanine green (ICG)] of the human prostate. Hemoglobin absorption mapped vascularity of the prostate and surroundings, whereas ICG absorption enhanced the intraprostatic photoacoustic contrast. Future work using the TRUSPA device for biomarker-specific molecular imaging may enable a fundamentally new approach to prostate cancer diagnosis, prognostication, and therapeutic monitoring.

Original languageEnglish (US)
Article numberaav2169
JournalScience Translational Medicine
Volume11
Issue number507
DOIs
StatePublished - Aug 28 2019

Fingerprint

Prostate
Molecular Imaging
Indocyanine Green
Ultrasonics
Hemoglobins
Equipment and Supplies
Needle Biopsy
Disease Management
Transducers
Ultrasonography
Prostatic Neoplasms
Anatomy
Biomarkers
Technology
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kothapalli, S. R., Sonn, G. A., Choe, J. W., Nikoozadeh, A., Bhuyan, A., Park, K. K., ... Gambhir, S. S. (2019). Simultaneous transrectal ultrasound and photoacoustic human prostate imaging. Science Translational Medicine, 11(507), [aav2169]. https://doi.org/10.1126/scitranslmed.aav2169
Kothapalli, Sri Rajasekhar ; Sonn, Geoffrey A. ; Choe, Jung Woo ; Nikoozadeh, Amin ; Bhuyan, Anshuman ; Park, Kwan Kyu ; Cristman, Paul ; Fan, Richard ; Moini, Azadeh ; Lee, Byung Chul ; Wu, Jonathan ; Carver, Thomas E. ; Trivedi, Dharati ; Shiiba, Lillian ; Steinberg, Idan ; Huland, David M. ; Rasmussen, Morten F. ; Liao, Joseph C. ; Brooks, James D. ; Khuri-Yakub, Pierre T. ; Gambhir, Sanjiv S. / Simultaneous transrectal ultrasound and photoacoustic human prostate imaging. In: Science Translational Medicine. 2019 ; Vol. 11, No. 507.
@article{fd8bd99f810f4cdd8cb1f8808e1b6875,
title = "Simultaneous transrectal ultrasound and photoacoustic human prostate imaging",
abstract = "Imaging technologies that simultaneously provide anatomical, functional, and molecular information are emerging as an attractive choice for disease screening and management. Since the 1980s, transrectal ultrasound (TRUS) has been routinely used to visualize prostatic anatomy and guide needle biopsy, despite limited specificity. Photoacoustic imaging (PAI) provides functional and molecular information at ultrasonic resolution based on optical absorption. Combining the strengths of TRUS and PAI approaches, we report the development and bench-to-bedside translation of an integrated TRUS and photoacoustic (TRUSPA) device. TRUSPA uses a miniaturized capacitive micromachined ultrasonic transducer array for simultaneous imaging of anatomical and molecular optical contrasts [intrinsic: hemoglobin; extrinsic: intravenous indocyanine green (ICG)] of the human prostate. Hemoglobin absorption mapped vascularity of the prostate and surroundings, whereas ICG absorption enhanced the intraprostatic photoacoustic contrast. Future work using the TRUSPA device for biomarker-specific molecular imaging may enable a fundamentally new approach to prostate cancer diagnosis, prognostication, and therapeutic monitoring.",
author = "Kothapalli, {Sri Rajasekhar} and Sonn, {Geoffrey A.} and Choe, {Jung Woo} and Amin Nikoozadeh and Anshuman Bhuyan and Park, {Kwan Kyu} and Paul Cristman and Richard Fan and Azadeh Moini and Lee, {Byung Chul} and Jonathan Wu and Carver, {Thomas E.} and Dharati Trivedi and Lillian Shiiba and Idan Steinberg and Huland, {David M.} and Rasmussen, {Morten F.} and Liao, {Joseph C.} and Brooks, {James D.} and Khuri-Yakub, {Pierre T.} and Gambhir, {Sanjiv S.}",
year = "2019",
month = "8",
day = "28",
doi = "10.1126/scitranslmed.aav2169",
language = "English (US)",
volume = "11",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "American Association for the Advancement of Science",
number = "507",

}

Kothapalli, SR, Sonn, GA, Choe, JW, Nikoozadeh, A, Bhuyan, A, Park, KK, Cristman, P, Fan, R, Moini, A, Lee, BC, Wu, J, Carver, TE, Trivedi, D, Shiiba, L, Steinberg, I, Huland, DM, Rasmussen, MF, Liao, JC, Brooks, JD, Khuri-Yakub, PT & Gambhir, SS 2019, 'Simultaneous transrectal ultrasound and photoacoustic human prostate imaging', Science Translational Medicine, vol. 11, no. 507, aav2169. https://doi.org/10.1126/scitranslmed.aav2169

Simultaneous transrectal ultrasound and photoacoustic human prostate imaging. / Kothapalli, Sri Rajasekhar; Sonn, Geoffrey A.; Choe, Jung Woo; Nikoozadeh, Amin; Bhuyan, Anshuman; Park, Kwan Kyu; Cristman, Paul; Fan, Richard; Moini, Azadeh; Lee, Byung Chul; Wu, Jonathan; Carver, Thomas E.; Trivedi, Dharati; Shiiba, Lillian; Steinberg, Idan; Huland, David M.; Rasmussen, Morten F.; Liao, Joseph C.; Brooks, James D.; Khuri-Yakub, Pierre T.; Gambhir, Sanjiv S.

In: Science Translational Medicine, Vol. 11, No. 507, aav2169, 28.08.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Simultaneous transrectal ultrasound and photoacoustic human prostate imaging

AU - Kothapalli, Sri Rajasekhar

AU - Sonn, Geoffrey A.

AU - Choe, Jung Woo

AU - Nikoozadeh, Amin

AU - Bhuyan, Anshuman

AU - Park, Kwan Kyu

AU - Cristman, Paul

AU - Fan, Richard

AU - Moini, Azadeh

AU - Lee, Byung Chul

AU - Wu, Jonathan

AU - Carver, Thomas E.

AU - Trivedi, Dharati

AU - Shiiba, Lillian

AU - Steinberg, Idan

AU - Huland, David M.

AU - Rasmussen, Morten F.

AU - Liao, Joseph C.

AU - Brooks, James D.

AU - Khuri-Yakub, Pierre T.

AU - Gambhir, Sanjiv S.

PY - 2019/8/28

Y1 - 2019/8/28

N2 - Imaging technologies that simultaneously provide anatomical, functional, and molecular information are emerging as an attractive choice for disease screening and management. Since the 1980s, transrectal ultrasound (TRUS) has been routinely used to visualize prostatic anatomy and guide needle biopsy, despite limited specificity. Photoacoustic imaging (PAI) provides functional and molecular information at ultrasonic resolution based on optical absorption. Combining the strengths of TRUS and PAI approaches, we report the development and bench-to-bedside translation of an integrated TRUS and photoacoustic (TRUSPA) device. TRUSPA uses a miniaturized capacitive micromachined ultrasonic transducer array for simultaneous imaging of anatomical and molecular optical contrasts [intrinsic: hemoglobin; extrinsic: intravenous indocyanine green (ICG)] of the human prostate. Hemoglobin absorption mapped vascularity of the prostate and surroundings, whereas ICG absorption enhanced the intraprostatic photoacoustic contrast. Future work using the TRUSPA device for biomarker-specific molecular imaging may enable a fundamentally new approach to prostate cancer diagnosis, prognostication, and therapeutic monitoring.

AB - Imaging technologies that simultaneously provide anatomical, functional, and molecular information are emerging as an attractive choice for disease screening and management. Since the 1980s, transrectal ultrasound (TRUS) has been routinely used to visualize prostatic anatomy and guide needle biopsy, despite limited specificity. Photoacoustic imaging (PAI) provides functional and molecular information at ultrasonic resolution based on optical absorption. Combining the strengths of TRUS and PAI approaches, we report the development and bench-to-bedside translation of an integrated TRUS and photoacoustic (TRUSPA) device. TRUSPA uses a miniaturized capacitive micromachined ultrasonic transducer array for simultaneous imaging of anatomical and molecular optical contrasts [intrinsic: hemoglobin; extrinsic: intravenous indocyanine green (ICG)] of the human prostate. Hemoglobin absorption mapped vascularity of the prostate and surroundings, whereas ICG absorption enhanced the intraprostatic photoacoustic contrast. Future work using the TRUSPA device for biomarker-specific molecular imaging may enable a fundamentally new approach to prostate cancer diagnosis, prognostication, and therapeutic monitoring.

UR - http://www.scopus.com/inward/record.url?scp=85071621932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071621932&partnerID=8YFLogxK

U2 - 10.1126/scitranslmed.aav2169

DO - 10.1126/scitranslmed.aav2169

M3 - Article

C2 - 31462508

AN - SCOPUS:85071621932

VL - 11

JO - Science Translational Medicine

JF - Science Translational Medicine

SN - 1946-6234

IS - 507

M1 - aav2169

ER -