Single-dose kinetics of nifedipine in rat plasma and brain

Piotr Janicki, D. Siembab, E. A. Paulo, P. Krzaścik

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Nifedipine concentrations in plasma and brain tissue of rats were assayed from 5 min to 4 h after an intravenous injection of 6 rng/kg body weight. Samples of rat plasma and homogenized brain tissue were extracted under sodium light with a dichloromethanepentane mixture. Analyses were done by high-performance liquid chromatography on a reverse-phase C18 column with electrochemical detection. The peak concentration of nifedipine in brain obtained after 10 min was 37 μg/g wet weight tissue, the half-life was 75 min. Apparently, nifedipine can easily cross the blood-brain barrier in the rat.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalPharmacology
Volume36
Issue number3
DOIs
StatePublished - Jan 1 1988

All Science Journal Classification (ASJC) codes

  • Pharmacology

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