Single-particle cryo-EM data acquisition by using direct electron detection camera

Shenping Wu, Jean-Paul Armache, Yifan Cheng

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Recent advances in single-particle electron cryo-microscopy (cryo-EM) were largely facilitated by the application of direct electron detection cameras. These cameras feature not only a significant improvement in detective quantum efficiency but also a high frame rate that enables images to be acquired as 'movies' made of stacks of many frames. In this review, we discuss how the applications of direct electron detection cameras in cryo-EM have changed the way the data are acquired.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalMicroscopy (Oxford, England)
Volume65
Issue number1
DOIs
StatePublished - Feb 1 2016

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Instrumentation
  • Radiology Nuclear Medicine and imaging

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