Single versus multiple session stereotactic body radiotherapy for spinal metastasis: The risk-benefit ratio

Kristin J. Redmond, Arjun Sahgal, Matthew Foote, Jonathan Knisely, Peter C. Gerszten, Samuel T. Chao, John H. Suh, Andrew E. Sloan, Eric L. Chang, Mitchell Machtay, Simon S. Lo

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Spine stereotactic body radiation therapy represents an important advancement in the management of spinal metastases that allows precise delivery of ablative doses of radiation therapy with excellent local control. Although the technique is being increasingly used in clinical practice, the optimal fractionation schedule remains uncertain. In this perspective paper, we review radiobiologic principles that support the use of multiple- versus single-fraction spine stereotactic body radiation therapy schedules and clinical data supporting the multiple-fraction approach. Specifically, we suggest that there may be a local control benefit of fractionation, while helping to limit the risk of toxicities such as vertebral body fracture, pain flare and radiation myelopathy. We conclude with future directions and the need for future study on this important topic.

Original languageEnglish (US)
Pages (from-to)2405-2415
Number of pages11
JournalFuture Oncology
Volume11
Issue number17
DOIs
StatePublished - Sep 1 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Single versus multiple session stereotactic body radiotherapy for spinal metastasis: The risk-benefit ratio'. Together they form a unique fingerprint.

Cite this