Six-month follow-up of naltrexone and psychotherapy for alcohol dependence

Stephanie S. O'Malley, Adam J. Jaffe, Grace Chang, Sarah Rode, Richard Schottenfeld, Roger Meyer, Bruce Rounsaville

Research output: Contribution to journalArticle

214 Citations (Scopus)

Abstract

Background: The goal of this study was to examine the persistence of naltrexone's effects on drinking out comes among alcoholics following discontinuation of treatment and to determine whether coping skills therapy improves long term outcomes compared with supportive therapy. Methods: Eighty of 97 alcohol-dependent subjects randomized to receive naltrexone or placebo and either coping skills therapy or supportive therapy for 12 weeks were assessed at a 6-month off-treatment follow-up. Results: Subjects who received naltrexone were less likely to drink heavily or to meet criteria for alcohol abuse or dependence than subjects who received placebo. The effect of naltrexone therapy on abstinence rates persisted only through the first month of follow-up. Coping skills therapy was associated with decreased levels of drinking among subjects who received placebo. Psychotherapy condition, however, did not predict alcohol diagnosis at follow-up. Conclusions: Some but not all of the benefits resulting from short-term naltrexone treatment persist after discontinuation of treatment. The findings suggest that continued treatment with naltrexone may be beneficial for some patients.

Original languageEnglish (US)
Pages (from-to)217-224
Number of pages8
JournalArchives of General Psychiatry
Volume53
Issue number3
DOIs
StatePublished - Jan 1 1996

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Naltrexone
Psychotherapy
Alcoholism
Psychological Adaptation
Therapeutics
Placebos
Drinking
Therapy
Alcohol
Alcohols
Alcoholics
Placebo

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

O'Malley, S. S., Jaffe, A. J., Chang, G., Rode, S., Schottenfeld, R., Meyer, R., & Rounsaville, B. (1996). Six-month follow-up of naltrexone and psychotherapy for alcohol dependence. Archives of General Psychiatry, 53(3), 217-224. https://doi.org/10.1001/archpsyc.1996.01830030039007
O'Malley, Stephanie S. ; Jaffe, Adam J. ; Chang, Grace ; Rode, Sarah ; Schottenfeld, Richard ; Meyer, Roger ; Rounsaville, Bruce. / Six-month follow-up of naltrexone and psychotherapy for alcohol dependence. In: Archives of General Psychiatry. 1996 ; Vol. 53, No. 3. pp. 217-224.
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O'Malley, SS, Jaffe, AJ, Chang, G, Rode, S, Schottenfeld, R, Meyer, R & Rounsaville, B 1996, 'Six-month follow-up of naltrexone and psychotherapy for alcohol dependence', Archives of General Psychiatry, vol. 53, no. 3, pp. 217-224. https://doi.org/10.1001/archpsyc.1996.01830030039007

Six-month follow-up of naltrexone and psychotherapy for alcohol dependence. / O'Malley, Stephanie S.; Jaffe, Adam J.; Chang, Grace; Rode, Sarah; Schottenfeld, Richard; Meyer, Roger; Rounsaville, Bruce.

In: Archives of General Psychiatry, Vol. 53, No. 3, 01.01.1996, p. 217-224.

Research output: Contribution to journalArticle

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