TY - JOUR
T1 - Skin-interfaced microfluidic devices with one-opening chambers and hydrophobic valves for sweat collection and analysis
AU - Zhang, Yingxue
AU - Chen, Yao
AU - Huang, Jielong
AU - Liu, Yangchengyi
AU - Peng, Jinfeng
AU - Chen, Shangda
AU - Song, Kui
AU - Ouyang, Xiaoping
AU - Cheng, Huanyu
AU - Wang, Xiufeng
N1 - Funding Information:
This research was supported by the National Natural Science Foundation of China (11872326 and 11702236), Natural Science Foundation of Hunan Province (2018JJ2379 and 2018JJ2396), Scientific Research Fund (18B089) of Hunan Provincial Education Department, and Open Fund from Institute of Flexible Electronics Technology of THU (2019KF1102). H. C. also acknowledges the support from Pennsylvania State University and American Chemical Society Petroleum Research Fund (59021-DNI7). The helpful discussion with W. Xia at Xi'an Jiaotong University is also acknowledged.
Publisher Copyright:
© 2020 The Royal Society of Chemistry.
PY - 2020/8/7
Y1 - 2020/8/7
N2 - Soft, skin-interfaced microfluidic platforms are capable of capturing, storing, and assessing sweat chemistry and total sweat loss, which provides essential insight into human physiological health. However, sweat loss from the outlet of the microfluidic devices often leads to deviation of the measured concentration of the biomarker or electrolyte from the actual value. Here, we introduce hydrophobic valves at the junction of the chamber and the microfluidic channel as a new chamber design to reduce sweat evaporation. Because the advancing front of the liquid in the hydrophilic microchannel is blocked by the hydrophobic valve, the fluid flows into the chambers, forms the initial meniscus, and completely fills the chambers along the initial meniscus. Fluid dynamic modeling and numerical simulations provide critical insights into the sweat sampling mechanism into the chambers. With significantly reduced evaporation and contamination, the sweat sample can be easily stored for a long time for later analysis when in situ analysis is limited. Additionally, the design with multiple chambers can allow sequential generation of sweat collection at different times for long-term analysis. The in situ real-time measurements of the sweat loss and pH value analysis from the human subject demonstrate the practical utility of the devices in collecting, storing, and analyzing the sweat generated from sweat glands on the skin. This journal is
AB - Soft, skin-interfaced microfluidic platforms are capable of capturing, storing, and assessing sweat chemistry and total sweat loss, which provides essential insight into human physiological health. However, sweat loss from the outlet of the microfluidic devices often leads to deviation of the measured concentration of the biomarker or electrolyte from the actual value. Here, we introduce hydrophobic valves at the junction of the chamber and the microfluidic channel as a new chamber design to reduce sweat evaporation. Because the advancing front of the liquid in the hydrophilic microchannel is blocked by the hydrophobic valve, the fluid flows into the chambers, forms the initial meniscus, and completely fills the chambers along the initial meniscus. Fluid dynamic modeling and numerical simulations provide critical insights into the sweat sampling mechanism into the chambers. With significantly reduced evaporation and contamination, the sweat sample can be easily stored for a long time for later analysis when in situ analysis is limited. Additionally, the design with multiple chambers can allow sequential generation of sweat collection at different times for long-term analysis. The in situ real-time measurements of the sweat loss and pH value analysis from the human subject demonstrate the practical utility of the devices in collecting, storing, and analyzing the sweat generated from sweat glands on the skin. This journal is
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U2 - 10.1039/d0lc00400f
DO - 10.1039/d0lc00400f
M3 - Article
C2 - 32555915
AN - SCOPUS:85088846980
VL - 20
SP - 2635
EP - 2645
JO - Lab on a Chip - Miniaturisation for Chemistry and Biology
JF - Lab on a Chip - Miniaturisation for Chemistry and Biology
SN - 1473-0197
IS - 15
ER -