Skin-surface cooling elicits peripheral and visceral vasoconstriction in humans

Thad E. Wilson, Charity L. Sauder, Matthew L. Kearney, Nathan T. Kuipers, Urs Leuenberger, Kevin D. Monahan, Chester A. Ray

Research output: Contribution to journalArticle

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Abstract

Skin-surface cooling elicits a pronounced systemic pressor response, which has previously been reported to be associated with peripheral vasoconstriction and may not fully account for the decrease in systemic vascular conductance. To test the hypothesis that whole body skin-surface cooling would also induce renal and splanchnic vasoconstriction, 14 supine subjects performed 26 skin-surface cooling trials (15-18°C water perfused through a tube-lined suit for 20 min). Oral and mean skin temperature, heart rate, stroke volume (Doppler ultrasound), mean arterial blood pressure (MAP), cutaneous blood velocity (laser-Doppler), and mean blood velocity of the brachial, celiac, renal, and superior mesenteric arteries (Doppler ultrasound) were measured during normothermia and skin-surface cooling. Cardiac output (heart rate · stroke volume) and indexes of vascular conductance (flux or blood velocity/MAP) were calculated. Skin-surface cooling increased MAP (n = 26; 78 ± 5 to 88 ± 5 mmHg; mean ± SD) and decreased mean skin temperature (n = 26; 33.7 ± 0.7 to 27.5 ± 1.2°C) and cutaneous (n = 12; 0.93 ± 0.68 to 0.36 ± 0.20 flux/mmHg), brachial (n = 10; 32 ± 15 to 20 ± 12), celiac (n = 8; 85 ± 22 to 73 ± 22 cm·s-1·mmHg-1), superior mesenteric (n = 8; 55 ± 16 to 48 ± 10 cm·s-1·mmHg -1), and renal (n = 8; 74 ± 26 to 64 ± 20 cm·s-1·mmHg-1; all P < 0.05) vascular conductance, without altering oral temperature, cardiac output, heart rate, or stroke volume. These data identify decreases in vascular conductance of skin and of brachial, celiac, superior mesenteric, and renal arteries. Thus it appears that vasoconstriction in both peripheral and visceral arteries contributes importantly to the pressor response produced during skin-surface cooling in humans.

Original languageEnglish (US)
Pages (from-to)1257-1262
Number of pages6
JournalJournal of applied physiology
Volume103
Issue number4
DOIs
StatePublished - Oct 1 2007

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Vasoconstriction
Skin
Arterial Pressure
Blood Vessels
Abdomen
Stroke Volume
Doppler Ultrasonography
Arm
Superior Mesenteric Artery
Skin Temperature
Heart Rate
Kidney
Cardiac Output
Cardiac Volume
Viscera
Renal Artery
Lasers
Arteries
Temperature
Water

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Wilson, T. E., Sauder, C. L., Kearney, M. L., Kuipers, N. T., Leuenberger, U., Monahan, K. D., & Ray, C. A. (2007). Skin-surface cooling elicits peripheral and visceral vasoconstriction in humans. Journal of applied physiology, 103(4), 1257-1262. https://doi.org/10.1152/japplphysiol.00401.2007
Wilson, Thad E. ; Sauder, Charity L. ; Kearney, Matthew L. ; Kuipers, Nathan T. ; Leuenberger, Urs ; Monahan, Kevin D. ; Ray, Chester A. / Skin-surface cooling elicits peripheral and visceral vasoconstriction in humans. In: Journal of applied physiology. 2007 ; Vol. 103, No. 4. pp. 1257-1262.
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Wilson, TE, Sauder, CL, Kearney, ML, Kuipers, NT, Leuenberger, U, Monahan, KD & Ray, CA 2007, 'Skin-surface cooling elicits peripheral and visceral vasoconstriction in humans', Journal of applied physiology, vol. 103, no. 4, pp. 1257-1262. https://doi.org/10.1152/japplphysiol.00401.2007

Skin-surface cooling elicits peripheral and visceral vasoconstriction in humans. / Wilson, Thad E.; Sauder, Charity L.; Kearney, Matthew L.; Kuipers, Nathan T.; Leuenberger, Urs; Monahan, Kevin D.; Ray, Chester A.

In: Journal of applied physiology, Vol. 103, No. 4, 01.10.2007, p. 1257-1262.

Research output: Contribution to journalArticle

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T1 - Skin-surface cooling elicits peripheral and visceral vasoconstriction in humans

AU - Wilson, Thad E.

AU - Sauder, Charity L.

AU - Kearney, Matthew L.

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AU - Monahan, Kevin D.

AU - Ray, Chester A.

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