Skull Impact on the Ultrasound Beam Profile of Transcranial Focused Ultrasound Stimulation

Pin Chien Tsai, Hesam Sadeghi Gougheri, Mehdi Kiani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Transcranial focused ultrasound stimulation (tFUS) is a promising noninvasive neuromodulation tool for targeting brain regions with millimeter-scale spatial resolutions. In conventional tFUS studies, a focused ultrasound beam generated by an external ultrasound transducer is delivered to the neural target. In tFUS, ultrasound should travel through the skull that features large attenuation and different acoustic impedance compared with the soft tissue, thereby resulting in acoustic impedance mismatch and reflections. In this paper, we study the impact of the rat skull on the ultrasound beam profile generated by both focused and unfocused (but with a natural focus) transducers at a wide sonication frequency (fp) range of 0.5-9.5 MHz. At different axial and lateral distances from the transducers, we measured ultrasound intensity profiles of three transducers operating at fps of 0.5 MHz, 1.2 MHz and 9.5 MHz with and without the skull. Our results showed that ultrasound beam profiles were significantly distorted by the skull. The transmission factor due to skull attenuation was measured 0.79,0.34 and 0.03 at fps of 0.5 MHz, 1.2 MHz and 9.5 MHz, respectively, when the skull was close to transducers focal zones.

Original languageEnglish (US)
Title of host publication2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages5188-5191
Number of pages4
ISBN (Electronic)9781538613115
DOIs
StatePublished - Jul 2019
Event41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 - Berlin, Germany
Duration: Jul 23 2019Jul 27 2019

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Conference

Conference41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019
CountryGermany
CityBerlin
Period7/23/197/27/19

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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    Tsai, P. C., Gougheri, H. S., & Kiani, M. (2019). Skull Impact on the Ultrasound Beam Profile of Transcranial Focused Ultrasound Stimulation. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 (pp. 5188-5191). [8857269] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2019.8857269