Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls: Results from a population-based study

William C. Reeves, Christine Marcelle Heim, Elizabeth M. Maloney, Laura Solomon Youngblood, Elizabeth R. Unger, Michael J. Decker, James F. Jones, David B. Rye

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Background: The etiology and pathophysiology of chronic fatigue syndrome (CFS) remain inchoate. Attempts to elucidate the pathophysiology must consider sleep physiology, as unrefreshing sleep is the most commonly reported of the 8 case-defining symptoms of CFS. Although published studies have consistently reported inefficient sleep and documented a variable occurrence of previously undiagnosed primary sleep disorders, they have not identified characteristic disturbances in sleep architecture or a distinctive pattern of polysomnographic abnormalities associated with CFS. Methods: This study recruited CFS cases and non-fatigued controls from a population based study of CFS in Wichita, Kansas. Participants spent two nights in the research unit of a local hospital and underwent overnight polysomnographic and daytime multiple sleep latency testing in order to characterize sleep architecture. Results: Approximately 18% of persons with CFS and 7% of asymptomatic controls were diagnosed with severe primary sleep disorders and were excluded from further analysis. These rates were not significantly different. Persons with CFS had a significantly higher mean frequency of obstructive apnea per hour (p = .003); however, the difference was not clinically meaningful. Other characteristics of sleep architecture did not differ between persons with CFS and controls. Conclusion: Although disordered breathing during sleep may be associated with CFS, this study generally did not provide evidence that altered.sleep architecture is a critical factor in CFS. Future studies should further scrutinize the relationship between subjective sleep quality relative to objective polysomnographic measures.

Original languageEnglish (US)
Article number41
JournalBMC Neurology
Volume6
DOIs
StatePublished - Nov 16 2006

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Chronic Fatigue Syndrome
Sleep
Population
Sleep Apnea Syndromes
Apnea

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Clinical Neurology

Cite this

Reeves, William C. ; Heim, Christine Marcelle ; Maloney, Elizabeth M. ; Youngblood, Laura Solomon ; Unger, Elizabeth R. ; Decker, Michael J. ; Jones, James F. ; Rye, David B. / Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls : Results from a population-based study. In: BMC Neurology. 2006 ; Vol. 6.
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Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls : Results from a population-based study. / Reeves, William C.; Heim, Christine Marcelle; Maloney, Elizabeth M.; Youngblood, Laura Solomon; Unger, Elizabeth R.; Decker, Michael J.; Jones, James F.; Rye, David B.

In: BMC Neurology, Vol. 6, 41, 16.11.2006.

Research output: Contribution to journalArticle

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AU - Reeves, William C.

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