Sleep Duration and Telomere Length in Children

Sarah James, Sara McLanahan, Jeanne Brooks-Gunn, Colter Mitchell, Lisa Schneper, Brandon Wagner, Daniel A. Notterman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective To test the association between sleep duration and telomere length in a pediatric population. Study design We analyzed cross-sectional data for 1567 children from the age 9 study wave of the Fragile Families and Child Wellbeing Study, a population-based birth cohort of children born between 1998 and 2000 in large American cities (population >200 000). We measured telomere length using quantitative polymerase chain reaction, and children's typical nightly sleep duration was reported by their primary caregivers. Using linear regression, we estimated the association between sleep duration and telomere length both in unadjusted models and adjusting for a number of covariates. Results We found that children with shorter sleep durations have shorter telomeres than children with longer sleep durations. Each hour less of nightly sleep duration is associated with having telomeres that are 0.015 log-kilobases per chromosome shorter (P <.05). We found no difference in this association by race, sex, or socioeconomic status. Conclusions We provide preliminary evidence that children with shorter sleep durations have shorter telomeres. This finding is consistent with a broader literature indicating that suboptimal sleep duration is a risk for increased physiological stress and impaired health. Future research should address the limitations of our study design by using longitudinal study designs and telomere measurements, measuring sleep duration via polysomnography or actigraphy, and assessing the intermediate biological mechanisms of the link between sleep and telomere dynamics.

Original languageEnglish (US)
Pages (from-to)247-252.e1
JournalJournal of Pediatrics
Volume187
DOIs
StatePublished - Aug 2017

Fingerprint

Telomere
Sleep
Actigraphy
Population
Physiological Stress
Polysomnography
Social Class
Caregivers
Longitudinal Studies
Linear Models
Chromosomes
Parturition
Pediatrics
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

James, S., McLanahan, S., Brooks-Gunn, J., Mitchell, C., Schneper, L., Wagner, B., & Notterman, D. A. (2017). Sleep Duration and Telomere Length in Children. Journal of Pediatrics, 187, 247-252.e1. https://doi.org/10.1016/j.jpeds.2017.05.014
James, Sarah ; McLanahan, Sara ; Brooks-Gunn, Jeanne ; Mitchell, Colter ; Schneper, Lisa ; Wagner, Brandon ; Notterman, Daniel A. / Sleep Duration and Telomere Length in Children. In: Journal of Pediatrics. 2017 ; Vol. 187. pp. 247-252.e1.
@article{721d38661eb14b82938ccaff6f8da947,
title = "Sleep Duration and Telomere Length in Children",
abstract = "Objective To test the association between sleep duration and telomere length in a pediatric population. Study design We analyzed cross-sectional data for 1567 children from the age 9 study wave of the Fragile Families and Child Wellbeing Study, a population-based birth cohort of children born between 1998 and 2000 in large American cities (population >200 000). We measured telomere length using quantitative polymerase chain reaction, and children's typical nightly sleep duration was reported by their primary caregivers. Using linear regression, we estimated the association between sleep duration and telomere length both in unadjusted models and adjusting for a number of covariates. Results We found that children with shorter sleep durations have shorter telomeres than children with longer sleep durations. Each hour less of nightly sleep duration is associated with having telomeres that are 0.015 log-kilobases per chromosome shorter (P <.05). We found no difference in this association by race, sex, or socioeconomic status. Conclusions We provide preliminary evidence that children with shorter sleep durations have shorter telomeres. This finding is consistent with a broader literature indicating that suboptimal sleep duration is a risk for increased physiological stress and impaired health. Future research should address the limitations of our study design by using longitudinal study designs and telomere measurements, measuring sleep duration via polysomnography or actigraphy, and assessing the intermediate biological mechanisms of the link between sleep and telomere dynamics.",
author = "Sarah James and Sara McLanahan and Jeanne Brooks-Gunn and Colter Mitchell and Lisa Schneper and Brandon Wagner and Notterman, {Daniel A.}",
year = "2017",
month = "8",
doi = "10.1016/j.jpeds.2017.05.014",
language = "English (US)",
volume = "187",
pages = "247--252.e1",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",

}

James, S, McLanahan, S, Brooks-Gunn, J, Mitchell, C, Schneper, L, Wagner, B & Notterman, DA 2017, 'Sleep Duration and Telomere Length in Children', Journal of Pediatrics, vol. 187, pp. 247-252.e1. https://doi.org/10.1016/j.jpeds.2017.05.014

Sleep Duration and Telomere Length in Children. / James, Sarah; McLanahan, Sara; Brooks-Gunn, Jeanne; Mitchell, Colter; Schneper, Lisa; Wagner, Brandon; Notterman, Daniel A.

In: Journal of Pediatrics, Vol. 187, 08.2017, p. 247-252.e1.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sleep Duration and Telomere Length in Children

AU - James, Sarah

AU - McLanahan, Sara

AU - Brooks-Gunn, Jeanne

AU - Mitchell, Colter

AU - Schneper, Lisa

AU - Wagner, Brandon

AU - Notterman, Daniel A.

PY - 2017/8

Y1 - 2017/8

N2 - Objective To test the association between sleep duration and telomere length in a pediatric population. Study design We analyzed cross-sectional data for 1567 children from the age 9 study wave of the Fragile Families and Child Wellbeing Study, a population-based birth cohort of children born between 1998 and 2000 in large American cities (population >200 000). We measured telomere length using quantitative polymerase chain reaction, and children's typical nightly sleep duration was reported by their primary caregivers. Using linear regression, we estimated the association between sleep duration and telomere length both in unadjusted models and adjusting for a number of covariates. Results We found that children with shorter sleep durations have shorter telomeres than children with longer sleep durations. Each hour less of nightly sleep duration is associated with having telomeres that are 0.015 log-kilobases per chromosome shorter (P <.05). We found no difference in this association by race, sex, or socioeconomic status. Conclusions We provide preliminary evidence that children with shorter sleep durations have shorter telomeres. This finding is consistent with a broader literature indicating that suboptimal sleep duration is a risk for increased physiological stress and impaired health. Future research should address the limitations of our study design by using longitudinal study designs and telomere measurements, measuring sleep duration via polysomnography or actigraphy, and assessing the intermediate biological mechanisms of the link between sleep and telomere dynamics.

AB - Objective To test the association between sleep duration and telomere length in a pediatric population. Study design We analyzed cross-sectional data for 1567 children from the age 9 study wave of the Fragile Families and Child Wellbeing Study, a population-based birth cohort of children born between 1998 and 2000 in large American cities (population >200 000). We measured telomere length using quantitative polymerase chain reaction, and children's typical nightly sleep duration was reported by their primary caregivers. Using linear regression, we estimated the association between sleep duration and telomere length both in unadjusted models and adjusting for a number of covariates. Results We found that children with shorter sleep durations have shorter telomeres than children with longer sleep durations. Each hour less of nightly sleep duration is associated with having telomeres that are 0.015 log-kilobases per chromosome shorter (P <.05). We found no difference in this association by race, sex, or socioeconomic status. Conclusions We provide preliminary evidence that children with shorter sleep durations have shorter telomeres. This finding is consistent with a broader literature indicating that suboptimal sleep duration is a risk for increased physiological stress and impaired health. Future research should address the limitations of our study design by using longitudinal study designs and telomere measurements, measuring sleep duration via polysomnography or actigraphy, and assessing the intermediate biological mechanisms of the link between sleep and telomere dynamics.

UR - http://www.scopus.com/inward/record.url?scp=85020057874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020057874&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2017.05.014

DO - 10.1016/j.jpeds.2017.05.014

M3 - Article

C2 - 28602380

AN - SCOPUS:85020057874

VL - 187

SP - 247-252.e1

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -

James S, McLanahan S, Brooks-Gunn J, Mitchell C, Schneper L, Wagner B et al. Sleep Duration and Telomere Length in Children. Journal of Pediatrics. 2017 Aug;187:247-252.e1. https://doi.org/10.1016/j.jpeds.2017.05.014