Sleep, microbes and cytokines

Janies M. Krueger, Linda A. Toth, Rachael Floyd, Jidong Fang, Levente Kapás, Sebastian Bredow, Ferenc Obál

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Dynamic changes in sleep in response to infectious challenge are a facet of the acute phase response. Changes in sleep induced by infection seem to be of recuperative value to the host. Furthermore, loss of sleep is associated with changes in immune function. Specific components of microbes such as mura- myl peptides or endotoxin from bacteria or double-stranded RNA from virus induce sleep responses. These microbial-induced responses are mediated via enhanced cytokine and hormone production. Interleukin-1, tumor necrosis factor and interferon-a are somnogenic. Interleukin-l-enhanced sleep involves growth hormone-releasing hormone. Microbial-cytokine-altered sleep results from an amplification of physiological sleep mechanisms.

Original languageEnglish (US)
Pages (from-to)100-109
Number of pages10
Issue number2
StatePublished - 1994

All Science Journal Classification (ASJC) codes

  • Immunology
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems


Dive into the research topics of 'Sleep, microbes and cytokines'. Together they form a unique fingerprint.

Cite this