SLIPS-lab-a bioinspired bioanalysis system for metabolic evaluation of urinary stone disease

Hui Li1, Eugene Shkolyar2, Jing Wang3, Jing Wang3, Simon Conti2, Simon Conti2, Alan C. Pao5, Alan C. Pao5, Joseph C. Liao2, Joseph C. Liao2, Tak Sing Wong1, Tak Sing Wong1, Tak Sing Wong1, Tak Sing Wong1, Pak Kin Wong1, Pak Kin Wong1, Pak Kin Wong1

Research output: Contribution to journalArticlepeer-review

Abstract

Urinary stone disease is among the most common medical conditions. Standard evaluation of urinary stone disease involves a metabolic workup of stone formers based on measurement of minerals and solutes excreted in 24-hour urine samples. Nevertheless, 24-hour urine testing is slow, expensive, and inconvenient for patients, which has hindered widespread adoption in clinical practice. Here, we demonstrate SLIPS-LAB (Slippery Liquid-Infused Porous Surface Laboratory), a droplet-based bioanalysis system, for rapid measurement of urinary stone- A ssociated analytes. The ultra-repellent and antifouling properties of SLIPS, which is a biologically inspired surface technology, allow autonomous liquid handling and manipulation of physiological samples without complicated sample preparation procedures and supporting equipment. We pilot a study that examines key urinary analytes in clinical samples from patients with urinary stone. The simplicity and speed of SLIPS-LAB hold the potential to provide actionable diagnostic information for patients with urinary stone disease and rapid feedback for responses to dietary and pharmacologic treatments.

Original languageEnglish (US)
Article numberEABA8535
JournalScience Advances
Volume6
Issue number21
DOIs
StatePublished - May 2020

All Science Journal Classification (ASJC) codes

  • General

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