SLIPS-lab-a bioinspired bioanalysis system for metabolic evaluation of urinary stone disease

Hui Li1; Eugene Shkolyar2; Jing Wang3; Jing Wang3; Simon Conti2; Simon Conti2; Alan C. Pao5; Alan C. Pao5; Joseph C. Liao2; Joseph C. Liao2; Tak Sing Wong1; Tak Sing Wong1; Tak Sing Wong1; Tak Sing Wong1; Pak Kin Wong1; Pak Kin Wong1; Pak Kin Wong1

doi:10.1126/sciadv.aba8535

SLIPS-lab-a bioinspired bioanalysis system for metabolic evaluation of urinary stone disease

Hui Li1, Eugene Shkolyar2, Jing Wang3, Jing Wang3, Simon Conti2, Simon Conti2, Alan C. Pao5, Alan C. Pao5, Joseph C. Liao2, Joseph C. Liao2, Tak Sing Wong1, Tak Sing Wong1, Tak Sing Wong1, Tak Sing Wong1, Pak Kin Wong1, Pak Kin Wong1, Pak Kin Wong1

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Urinary stone disease is among the most common medical conditions. Standard evaluation of urinary stone disease involves a metabolic workup of stone formers based on measurement of minerals and solutes excreted in 24-hour urine samples. Nevertheless, 24-hour urine testing is slow, expensive, and inconvenient for patients, which has hindered widespread adoption in clinical practice. Here, we demonstrate SLIPS-LAB (Slippery Liquid-Infused Porous Surface Laboratory), a droplet-based bioanalysis system, for rapid measurement of urinary stone- A ssociated analytes. The ultra-repellent and antifouling properties of SLIPS, which is a biologically inspired surface technology, allow autonomous liquid handling and manipulation of physiological samples without complicated sample preparation procedures and supporting equipment. We pilot a study that examines key urinary analytes in clinical samples from patients with urinary stone. The simplicity and speed of SLIPS-LAB hold the potential to provide actionable diagnostic information for patients with urinary stone disease and rapid feedback for responses to dietary and pharmacologic treatments.

Original language	English (US)
Article number	EABA8535
Journal	Science Advances
Volume	6
Issue number	21
DOIs	https://doi.org/10.1126/sciadv.aba8535
State	Published - May 2020

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Li1, H., Shkolyar2, E., Wang3, J., Wang3, J., Conti2, S., Conti2, S., Pao5, A. C., Pao5, A. C., Liao2, J. C., Liao2, J. C., Wong1, T. S., Wong1, T. S., Wong1, T. S., Wong1, T. S., Wong1, P. K., Wong1, P. K., & Wong1, P. K. (2020). SLIPS-lab-a bioinspired bioanalysis system for metabolic evaluation of urinary stone disease. Science Advances, 6(21), [EABA8535]. https://doi.org/10.1126/sciadv.aba8535

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title = "SLIPS-lab-a bioinspired bioanalysis system for metabolic evaluation of urinary stone disease",

abstract = "Urinary stone disease is among the most common medical conditions. Standard evaluation of urinary stone disease involves a metabolic workup of stone formers based on measurement of minerals and solutes excreted in 24-hour urine samples. Nevertheless, 24-hour urine testing is slow, expensive, and inconvenient for patients, which has hindered widespread adoption in clinical practice. Here, we demonstrate SLIPS-LAB (Slippery Liquid-Infused Porous Surface Laboratory), a droplet-based bioanalysis system, for rapid measurement of urinary stone- A ssociated analytes. The ultra-repellent and antifouling properties of SLIPS, which is a biologically inspired surface technology, allow autonomous liquid handling and manipulation of physiological samples without complicated sample preparation procedures and supporting equipment. We pilot a study that examines key urinary analytes in clinical samples from patients with urinary stone. The simplicity and speed of SLIPS-LAB hold the potential to provide actionable diagnostic information for patients with urinary stone disease and rapid feedback for responses to dietary and pharmacologic treatments.",

author = "Hui Li1 and Eugene Shkolyar2 and Jing Wang3 and Jing Wang3 and Simon Conti2 and Simon Conti2 and Pao5, {Alan C.} and Pao5, {Alan C.} and Liao2, {Joseph C.} and Liao2, {Joseph C.} and Wong1, {Tak Sing} and Wong1, {Tak Sing} and Wong1, {Tak Sing} and Wong1, {Tak Sing} and Wong1, {Pak Kin} and Wong1, {Pak Kin} and Wong1, {Pak Kin}",

year = "2020",

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doi = "10.1126/sciadv.aba8535",

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AU - Li1, Hui

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AU - Pao5, Alan C.

AU - Liao2, Joseph C.

AU - Wong1, Tak Sing

AU - Wong1, Pak Kin

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SLIPS-lab-a bioinspired bioanalysis system for metabolic evaluation of urinary stone disease

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