Slowed information processing in HIV-1 disease

Antolin M. Llorente, Eric N. Miller, Louis F. D'Elia, Ola A. Selnes, Jerry Wesch, James T. Becker, Paul Satz

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

This investigation examined the effects of HIV-1 infection on speeded complex cognitive processing in a group of HIV-negative (n = 666), HIV- positive symptomatic (n = 156), and HIV-positive asymptomatic (n = 623) participants while controlling for the effects of slowed motor functioning, peripheral neuropathy, and several other putative confounds. Stroop Interference and reaction-time tasks served as anchor procedures to assess cognitive processing. The present findings suggest that HIV-1 infection is capable of compromising CNS-mediated cognitive processes (speeded processing) infringing upon their efficacy in the symptomatic stages of the disease while sparing individuals in the asymptomatic stage. The detrimental effects observed on information-processing mechanisms associated with HIV infection persisted despite the use of procedures to control for peripheral nerve integrity and other potential confounds.

Original languageEnglish (US)
Pages (from-to)60-72
Number of pages13
JournalJournal of Clinical and Experimental Neuropsychology
Volume20
Issue number1
DOIs
StatePublished - Jul 20 1998

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Neurology
  • Clinical Neurology

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