Wireless monitoring of Cardiac activity for diagnostic purposes as well as rehabilitative applications has gained significant traction over the past decade. The integration of the nanotextile-based sensors in regular clothing can make the health monitoring system completely unobtrusive and “invisible” for everyday use. A significant research effort has been underway to bring these technologies out of the lab and encourage their use in clinical practice. In this paper, we review the promising efforts made in this direction and address some of the remaining impediments to the wide adoption of these technologies. Based on the existing literature, we conclude that the clinical adoption of these systems may require a trade-off between existing diagnostic techniques for Cardiovascular Diseases (CVDs) and techniques that can be reproducibly and robustly implemented on textiles.We focus specifically on the measurement of Cardiac Biopotentials (CBP) using smart nanotextile garments and wireless systems.