Smooth muscle myosin heavy chain locus (myh11) maps to 16p13.13-p13.12 and establishes a new region of conserved synteny between human 16p and mouse 16

Zuoming Deng, Pu Liu, Paula Marlton, David F. Claxton, Sharon Lane, David F. Callen, Francis S. Collins, Michael J. Siciliano

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The human smooth myosin heavy chain locus (MYH11) was mapped by fluorescence in situ hybridization to the middle of the p arm of chromosome 16 using a genomic cosmid clone containing coding sequences of the gene as probe. Probe from coding sequence, when applied to Southern blots of a panel of hybrids containing different portions of human chromosome 16, localized the gene to 16p13.13-13.12. Coding sequence PCR primers, when used on the DNA from a CHO-mouse hybrid clone mapping panel informative for mouse chromosomes, showed that the gene was located on mouse chromosome 16. These results correct a recent assignment of MYH11 from 16q12.2 to the region of the 16p-arm inversion breakpoint seen in acute myelomonocytic leukemia (AMML) M4Eo and demonstrate that the conflicting data do not result from the presence of additional MYH genes on the q arm of the chromosome. Also, a new region of conserved synteny between human 16p and mouse 16 is established.

Original languageEnglish (US)
Pages (from-to)156-159
Number of pages4
JournalGenomics
Volume18
Issue number1
DOIs
StatePublished - Oct 1993

All Science Journal Classification (ASJC) codes

  • Genetics

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