Sodium renal imaging in mice at high magnetic fields

Thomas Neuberger, Vikas Gulani, Andrew Webb

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

This work presents the first sodium MRI functional renal study on a mouse model. The tissue sodium concentration was monitored during induced diuresis with furosemide. By using density-weighted chemical shift imaging (DWCSI) at high field strength a temporal resolution of less than 5 min for three dimensional (3D) data sets with high spatial resolution was achieved. A maximum increase of 20% in the cortex and a decrease of 45% of the original signal strength in the medulla were observed. These findings correspond well with experiments conducted on much larger rodent models.

Original languageEnglish (US)
Pages (from-to)1067-1071
Number of pages5
JournalMagnetic Resonance in Medicine
Volume58
Issue number5
DOIs
StatePublished - Nov 2007

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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