Solutal and thermal buoyancy effects in self-powered phosphatase micropumps

Lyanne Valdez, Henry Shum, Isamar Ortiz-Rivera, Anna C. Balazs, Ayusman Sen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Immobilized enzymes generate net fluid flow when exposed to specific reagents in solution. Thus, they function as self-powered platforms that combine sensing and on-demand fluid pumping. To uncover the mechanism of pumping, we examine the effects of solutal and thermal buoyancy on the behavior of phosphatase-based micropumps, using a series of reactants with known thermodynamic and kinetic parameters. By combining modeling and experiments, we perform the first quantitative comparison of thermal and solutal effects in an enzyme micropump system. Despite the significant exothermicity of the catalyzed reactions, we find that thermal effects play a minimal role in the observed fluid flow. Instead, fluid transport in phosphatase micropumps is governed by the density difference between the reactants and the products of the reaction. This surprising conclusion suggests new design principles for catalytic pumps.

Original languageEnglish (US)
Pages (from-to)2800-2807
Number of pages8
JournalSoft Matter
Volume13
Issue number15
DOIs
StatePublished - Jan 1 2017

Fingerprint

phosphatases
Buoyancy
Phosphoric Monoester Hydrolases
buoyancy
fluid flow
temperature effects
enzymes
Flow of fluids
pumping
Immobilized Enzymes
Fluids
fluids
Kinetic parameters
Thermal effects
reagents
platforms
Pumps
Thermodynamics
pumps
thermodynamics

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Valdez, Lyanne ; Shum, Henry ; Ortiz-Rivera, Isamar ; Balazs, Anna C. ; Sen, Ayusman. / Solutal and thermal buoyancy effects in self-powered phosphatase micropumps. In: Soft Matter. 2017 ; Vol. 13, No. 15. pp. 2800-2807.
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Valdez, L, Shum, H, Ortiz-Rivera, I, Balazs, AC & Sen, A 2017, 'Solutal and thermal buoyancy effects in self-powered phosphatase micropumps', Soft Matter, vol. 13, no. 15, pp. 2800-2807. https://doi.org/10.1039/c7sm00022g

Solutal and thermal buoyancy effects in self-powered phosphatase micropumps. / Valdez, Lyanne; Shum, Henry; Ortiz-Rivera, Isamar; Balazs, Anna C.; Sen, Ayusman.

In: Soft Matter, Vol. 13, No. 15, 01.01.2017, p. 2800-2807.

Research output: Contribution to journalArticle

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