Solvent effects on host-guest complexation

J. N. Spencer, J. E. Mihalick, I. M. Paul, W. J. Nicholson, T. J. Nicholson, X. Ke, Q. He, F. J. Carter, S. E. Daniels, L. J. Fenton, J. L. Ealy, S. Puppala, C. H. Yoder

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Complex formation between 15-crown-5 and malononitrile was studied in twelve solvents by calorimetry. Thermodynamic parameters for the crown ether adduct were determined and used in a LFER analysis to ascertain the solvent effects on the complexation process. Enthalpy of solution data show that malononitrile is solvated by electron pair donation by the solvents and the crown ether is solvated by donating electron pairs to the solvents. The complex is more solvated than the monomers.

Original languageEnglish (US)
Pages (from-to)711-720
Number of pages10
JournalJournal of Solution Chemistry
Issue number6
StatePublished - Jun 1 1994

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Physical and Theoretical Chemistry


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