Solvent-non-solvent rapid-injection for preparing nanostructured materials from micelles to hydrogels

Chao Lang, Jacob A. LaNasa, Nyalaliska Utomo, Yifan Xu, Melissa J. Nelson, Woochul Song, Michael Anthony Hickner, Ralph H. Colby, Manish Kumar, Robert John Hickey, III

Research output: Contribution to journalArticle

Abstract

Due to their distinctive molecular architecture, ABA triblock copolymers will undergo specific self-assembly processes into various nanostructures upon introduction into a B-block selective solvent. Although much of the focus in ABA triblock copolymer self-assembly has been on equilibrium nanostructures, little attention has been paid to the guiding principles of nanostructure formation during non-equilibrium processing conditions. Here we report a universal and quantitative method for fabricating and controlling ABA triblock copolymer hierarchical structures using solvent-non-solvent rapid-injection processing. Plasmonic nanocomposite hydrogels containing gold nanoparticles and hierarchically-ordered hydrogels exhibiting structural color can be assembled within one minute using this rapid-injection technique. Surprisingly, the rapid-injection hydrogels display superior mechanical properties compared with those of conventional ABA hydrogels. This work will allow for translation into technologically relevant areas such as drug delivery, tissue engineering, regenerative medicine, and soft robotics, in which structure and mechanical property precision are essential.

Original languageEnglish (US)
Article number3855
JournalNature communications
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2019

Fingerprint

Hydrogels
Nanostructures
Micelles
Nanostructured materials
micelles
copolymers
injection
Block copolymers
Injections
self assembly
mechanical properties
Self assembly
tissue engineering
robotics
medicine
Nanocomposites
Mechanical properties
Regenerative Medicine
delivery
nanocomposites

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Lang, Chao ; LaNasa, Jacob A. ; Utomo, Nyalaliska ; Xu, Yifan ; Nelson, Melissa J. ; Song, Woochul ; Hickner, Michael Anthony ; Colby, Ralph H. ; Kumar, Manish ; Hickey, III, Robert John. / Solvent-non-solvent rapid-injection for preparing nanostructured materials from micelles to hydrogels. In: Nature communications. 2019 ; Vol. 10, No. 1.
@article{ebd3990bd4004baba47985e817cf8bb2,
title = "Solvent-non-solvent rapid-injection for preparing nanostructured materials from micelles to hydrogels",
abstract = "Due to their distinctive molecular architecture, ABA triblock copolymers will undergo specific self-assembly processes into various nanostructures upon introduction into a B-block selective solvent. Although much of the focus in ABA triblock copolymer self-assembly has been on equilibrium nanostructures, little attention has been paid to the guiding principles of nanostructure formation during non-equilibrium processing conditions. Here we report a universal and quantitative method for fabricating and controlling ABA triblock copolymer hierarchical structures using solvent-non-solvent rapid-injection processing. Plasmonic nanocomposite hydrogels containing gold nanoparticles and hierarchically-ordered hydrogels exhibiting structural color can be assembled within one minute using this rapid-injection technique. Surprisingly, the rapid-injection hydrogels display superior mechanical properties compared with those of conventional ABA hydrogels. This work will allow for translation into technologically relevant areas such as drug delivery, tissue engineering, regenerative medicine, and soft robotics, in which structure and mechanical property precision are essential.",
author = "Chao Lang and LaNasa, {Jacob A.} and Nyalaliska Utomo and Yifan Xu and Nelson, {Melissa J.} and Woochul Song and Hickner, {Michael Anthony} and Colby, {Ralph H.} and Manish Kumar and {Hickey, III}, {Robert John}",
year = "2019",
month = "12",
day = "1",
doi = "10.1038/s41467-019-11804-7",
language = "English (US)",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

Solvent-non-solvent rapid-injection for preparing nanostructured materials from micelles to hydrogels. / Lang, Chao; LaNasa, Jacob A.; Utomo, Nyalaliska; Xu, Yifan; Nelson, Melissa J.; Song, Woochul; Hickner, Michael Anthony; Colby, Ralph H.; Kumar, Manish; Hickey, III, Robert John.

In: Nature communications, Vol. 10, No. 1, 3855, 01.12.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Solvent-non-solvent rapid-injection for preparing nanostructured materials from micelles to hydrogels

AU - Lang, Chao

AU - LaNasa, Jacob A.

AU - Utomo, Nyalaliska

AU - Xu, Yifan

AU - Nelson, Melissa J.

AU - Song, Woochul

AU - Hickner, Michael Anthony

AU - Colby, Ralph H.

AU - Kumar, Manish

AU - Hickey, III, Robert John

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Due to their distinctive molecular architecture, ABA triblock copolymers will undergo specific self-assembly processes into various nanostructures upon introduction into a B-block selective solvent. Although much of the focus in ABA triblock copolymer self-assembly has been on equilibrium nanostructures, little attention has been paid to the guiding principles of nanostructure formation during non-equilibrium processing conditions. Here we report a universal and quantitative method for fabricating and controlling ABA triblock copolymer hierarchical structures using solvent-non-solvent rapid-injection processing. Plasmonic nanocomposite hydrogels containing gold nanoparticles and hierarchically-ordered hydrogels exhibiting structural color can be assembled within one minute using this rapid-injection technique. Surprisingly, the rapid-injection hydrogels display superior mechanical properties compared with those of conventional ABA hydrogels. This work will allow for translation into technologically relevant areas such as drug delivery, tissue engineering, regenerative medicine, and soft robotics, in which structure and mechanical property precision are essential.

AB - Due to their distinctive molecular architecture, ABA triblock copolymers will undergo specific self-assembly processes into various nanostructures upon introduction into a B-block selective solvent. Although much of the focus in ABA triblock copolymer self-assembly has been on equilibrium nanostructures, little attention has been paid to the guiding principles of nanostructure formation during non-equilibrium processing conditions. Here we report a universal and quantitative method for fabricating and controlling ABA triblock copolymer hierarchical structures using solvent-non-solvent rapid-injection processing. Plasmonic nanocomposite hydrogels containing gold nanoparticles and hierarchically-ordered hydrogels exhibiting structural color can be assembled within one minute using this rapid-injection technique. Surprisingly, the rapid-injection hydrogels display superior mechanical properties compared with those of conventional ABA hydrogels. This work will allow for translation into technologically relevant areas such as drug delivery, tissue engineering, regenerative medicine, and soft robotics, in which structure and mechanical property precision are essential.

UR - http://www.scopus.com/inward/record.url?scp=85071488992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071488992&partnerID=8YFLogxK

U2 - 10.1038/s41467-019-11804-7

DO - 10.1038/s41467-019-11804-7

M3 - Article

C2 - 31451686

AN - SCOPUS:85071488992

VL - 10

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 3855

ER -