Somatic genetic alterations (LOH) in benign, borderline and invasive ovarian tumours: Intratumoral molecular heterogeneity

Irina Zborovskaya, Alexander Gasparian, Appolon Karseladze, Irina Elcheva, Elena Trofimova, Keltouma Driouch, Martine Trassard, Alexander Tatosyan, Rosette Lidereau

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Loss of heterozygosity (LOH) affects a number of chromosome regions in ovarian cancer, pointing to the possible involvement of tumour-suppressor genes in ovarian tumorigenesis. We performed comparative analysis of allelic loss at 6 frequently affected chromosome regions in a panel of 53 benign, borderline and malignant ovarian tumours. Precursor lesions could provide evidence that an accumulation of genetic events is required for normal ovarian epithelium to generate malignant tumours. LOH on chromosome I p was relatively common in benign, borderline and malignant tumours, while at lip and 7q it was observed not only in invasive but also in borderline tumours. Moreover, 17q and 18q were affected mainly in advanced malignant tumours and revealed a high frequency of clonal intratumoral heterogeneity. We encountered different spectra of genetic alterations in primary tumours and their metastasis, which may be the results of intratumoral heterogeneity leading to dissemination in only some sub-clones.

Original languageEnglish (US)
Pages (from-to)822-826
Number of pages5
JournalInternational Journal of Cancer
Volume82
Issue number6
DOIs
StatePublished - 1999

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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