Sonodynamic therapy inhibits angiogenesis and tumor growth in a xenograft mouse model

Zhongxiuzi Gao, Jinhua Zheng, Bin Yang, Zhu Wang, Haixia Fan, Yanhong Lv, Haixia Li, Limin Jia, Wenwu Cao

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Abstract

Studies of sonodynamic therapy (SDT) have mainly focused on its direct cytotoxic effect on tumor cells. Its effects on the tumor microenvironment, especially angiogenesis, remain unknown. In this study, we found that SDT significantly inhibited endothelial cell proliferation, migration, invasion, and tube formation. Furthermore, in a tumor xenograft mouse model, SDT was found to remarkably suppress tumor growth, intratumoral vascularity, and expression of vascular endothelial growth factor in tumor cells. An ultrastructural study showed damage and disruption of tumor microvasculature after STD. Our results indicate that SDT inhibits neovascularization in tumor, which is partially responsible for the anti-tumor effect of SDT.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalCancer Letters
Volume335
Issue number1
DOIs
Publication statusPublished - Jul 10 2013

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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