Sorting out the functional role(s) of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in cell proliferation and cancer

Jeffrey M. Peters, Frank J. Gonzalez

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations

Abstract

Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) has many beneficial physiological functions ranging from enhancing fatty acid catabolism, improving insulin sensitivity, inhibiting inflammation and increasing oxidative myofibers allowing for improved athletic performance. Thus, given the potential for targeting PPARβ/δ for the prevention and/or treatment of diseases including diabetes, dyslipidemias, metabolic syndrome and cancer, it is critical to clarify the functional role of PPARβ/δ in cell proliferation and associated disorders such as cancer. However, there is considerable controversy whether PPARβ/δ stimulates or inhibits cell proliferation. This review summarizes the literature describing the influence of PPARβ/δ on cell proliferation, with an emphasis toward dissecting the data that give rise to opposing hypotheses. Suggestions are offered to standardize measurements associated with these studies so that interlaboratory comparisons can be accurately assessed.

Original languageEnglish (US)
Pages (from-to)230-241
Number of pages12
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1796
Issue number2
DOIs
StatePublished - Dec 2009

All Science Journal Classification (ASJC) codes

  • Oncology
  • Genetics
  • Cancer Research

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