SPARCL1 suppresses metastasis in prostate cancer

Yuzhu Xiang, Qingchao Qiu, Ming Jiang, Renjie Jin, Brian D. Lehmann, Douglas W. Strand, Bojana Jovanovic, David Degraff, Yi Zheng, Dina A. Yousif, Christine Q. Simmons, Thomas C. Case, Jia Yi, Justin M. Cates, John Virostko, Xiusheng He, Xunbo Jin, Simon W. Hayward, Robert J. Matusik, Alfred L. GeorgeYajun Yi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose: Metastasis, the main cause of death from cancer, remains poorly understood at the molecular level. Experimental design: Based on a pattern of reduced expression in human prostate cancer tissues and tumor cell lines, a candidate suppressor gene (SPARCL1) was identified. We used invitro approaches to determine whether overexpression of SPARCL1 affects cell growth, migration, and invasiveness. We then employed xenograft mouse models to analyze the impact of SPARCL1 on prostate cancer cell growth and metastasis invivo. Results: SPARCL1 expression did not inhibit tumor cell proliferation invitro. By contrast, SPARCL1 did suppress tumor cell migration and invasiveness invitro and tumor metastatic growth invivo, conferring improved survival in xenograft mouse models. Conclusions: We present the first invivo data suggesting that SPARCL1 suppresses metastasis of prostate cancer.

Original languageEnglish (US)
Pages (from-to)1019-1030
Number of pages12
JournalMolecular Oncology
Volume7
Issue number6
DOIs
StatePublished - Jan 1 2013

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Prostatic Neoplasms
Neoplasm Metastasis
Heterografts
Cell Movement
Neoplasms
Growth
Suppressor Genes
Tumor Cell Line
Cause of Death
Research Design
Cell Proliferation
Survival

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Oncology
  • Cancer Research

Cite this

Xiang, Y., Qiu, Q., Jiang, M., Jin, R., Lehmann, B. D., Strand, D. W., ... Yi, Y. (2013). SPARCL1 suppresses metastasis in prostate cancer. Molecular Oncology, 7(6), 1019-1030. https://doi.org/10.1016/j.molonc.2013.07.008
Xiang, Yuzhu ; Qiu, Qingchao ; Jiang, Ming ; Jin, Renjie ; Lehmann, Brian D. ; Strand, Douglas W. ; Jovanovic, Bojana ; Degraff, David ; Zheng, Yi ; Yousif, Dina A. ; Simmons, Christine Q. ; Case, Thomas C. ; Yi, Jia ; Cates, Justin M. ; Virostko, John ; He, Xiusheng ; Jin, Xunbo ; Hayward, Simon W. ; Matusik, Robert J. ; George, Alfred L. ; Yi, Yajun. / SPARCL1 suppresses metastasis in prostate cancer. In: Molecular Oncology. 2013 ; Vol. 7, No. 6. pp. 1019-1030.
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author = "Yuzhu Xiang and Qingchao Qiu and Ming Jiang and Renjie Jin and Lehmann, {Brian D.} and Strand, {Douglas W.} and Bojana Jovanovic and David Degraff and Yi Zheng and Yousif, {Dina A.} and Simmons, {Christine Q.} and Case, {Thomas C.} and Jia Yi and Cates, {Justin M.} and John Virostko and Xiusheng He and Xunbo Jin and Hayward, {Simon W.} and Matusik, {Robert J.} and George, {Alfred L.} and Yajun Yi",
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Xiang, Y, Qiu, Q, Jiang, M, Jin, R, Lehmann, BD, Strand, DW, Jovanovic, B, Degraff, D, Zheng, Y, Yousif, DA, Simmons, CQ, Case, TC, Yi, J, Cates, JM, Virostko, J, He, X, Jin, X, Hayward, SW, Matusik, RJ, George, AL & Yi, Y 2013, 'SPARCL1 suppresses metastasis in prostate cancer', Molecular Oncology, vol. 7, no. 6, pp. 1019-1030. https://doi.org/10.1016/j.molonc.2013.07.008

SPARCL1 suppresses metastasis in prostate cancer. / Xiang, Yuzhu; Qiu, Qingchao; Jiang, Ming; Jin, Renjie; Lehmann, Brian D.; Strand, Douglas W.; Jovanovic, Bojana; Degraff, David; Zheng, Yi; Yousif, Dina A.; Simmons, Christine Q.; Case, Thomas C.; Yi, Jia; Cates, Justin M.; Virostko, John; He, Xiusheng; Jin, Xunbo; Hayward, Simon W.; Matusik, Robert J.; George, Alfred L.; Yi, Yajun.

In: Molecular Oncology, Vol. 7, No. 6, 01.01.2013, p. 1019-1030.

Research output: Contribution to journalArticle

TY - JOUR

T1 - SPARCL1 suppresses metastasis in prostate cancer

AU - Xiang, Yuzhu

AU - Qiu, Qingchao

AU - Jiang, Ming

AU - Jin, Renjie

AU - Lehmann, Brian D.

AU - Strand, Douglas W.

AU - Jovanovic, Bojana

AU - Degraff, David

AU - Zheng, Yi

AU - Yousif, Dina A.

AU - Simmons, Christine Q.

AU - Case, Thomas C.

AU - Yi, Jia

AU - Cates, Justin M.

AU - Virostko, John

AU - He, Xiusheng

AU - Jin, Xunbo

AU - Hayward, Simon W.

AU - Matusik, Robert J.

AU - George, Alfred L.

AU - Yi, Yajun

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Purpose: Metastasis, the main cause of death from cancer, remains poorly understood at the molecular level. Experimental design: Based on a pattern of reduced expression in human prostate cancer tissues and tumor cell lines, a candidate suppressor gene (SPARCL1) was identified. We used invitro approaches to determine whether overexpression of SPARCL1 affects cell growth, migration, and invasiveness. We then employed xenograft mouse models to analyze the impact of SPARCL1 on prostate cancer cell growth and metastasis invivo. Results: SPARCL1 expression did not inhibit tumor cell proliferation invitro. By contrast, SPARCL1 did suppress tumor cell migration and invasiveness invitro and tumor metastatic growth invivo, conferring improved survival in xenograft mouse models. Conclusions: We present the first invivo data suggesting that SPARCL1 suppresses metastasis of prostate cancer.

AB - Purpose: Metastasis, the main cause of death from cancer, remains poorly understood at the molecular level. Experimental design: Based on a pattern of reduced expression in human prostate cancer tissues and tumor cell lines, a candidate suppressor gene (SPARCL1) was identified. We used invitro approaches to determine whether overexpression of SPARCL1 affects cell growth, migration, and invasiveness. We then employed xenograft mouse models to analyze the impact of SPARCL1 on prostate cancer cell growth and metastasis invivo. Results: SPARCL1 expression did not inhibit tumor cell proliferation invitro. By contrast, SPARCL1 did suppress tumor cell migration and invasiveness invitro and tumor metastatic growth invivo, conferring improved survival in xenograft mouse models. Conclusions: We present the first invivo data suggesting that SPARCL1 suppresses metastasis of prostate cancer.

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DO - 10.1016/j.molonc.2013.07.008

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Xiang Y, Qiu Q, Jiang M, Jin R, Lehmann BD, Strand DW et al. SPARCL1 suppresses metastasis in prostate cancer. Molecular Oncology. 2013 Jan 1;7(6):1019-1030. https://doi.org/10.1016/j.molonc.2013.07.008