Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells

Changya Chen, Wenbao Yu, Joanna Tober, Peng Gao, Bing He, Kiwon Lee, Tuan Trieu, Gerd A. Blobel, Nancy A. Speck, Kai Tan

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A developmental transition occurs between fetal and adult hematopoietic stem cells. How the 3D genome folding contributes to this transition is poorly understood. Chen et al. show global genome organization is largely conserved, but a large fraction of enhancer-promoter interactions is re-organized and regulate genes contributing to the phenotypic differences.

Original languageEnglish (US)
Pages (from-to)4200-4211.e7
JournalCell Reports
Volume29
Issue number12
DOIs
StatePublished - Dec 17 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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