Specific bronchoalveolar lavage IgG antibody in hypersensitivity pneumonitis from diphenylmethane diisocyanate

Rebecca Bascom, T. P. Kennedy, D. Levitz, C. R. Zeiss

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We evaluated a patient for dyspnea, fever, malaise, and hypoxemia that developed after exposure to diphenylmethane diisocyanate (MDI). Specific inhalation challenge with MDI caused fever, leukocytosis, a restrictive decline in forced vital capacity, and a decrease in Pa(O2) several hours after challenge. Bronchoalveolar lavage 24 h after challenge showed lymphocytic alveolitis. Specific IgG antibodies to MDI human serum albumin (MDI-HSA) conjugate were demonstrated in serum and bronchial lavage fluid using the enzyme-linked immunoabsorbent (ELISA) technique. These findings suggest participation of both humoral and cellular immunity in the pathogenesis of hypersensitivity pneumonitis from isocyanate exposure.

Original languageEnglish (US)
Pages (from-to)463-465
Number of pages3
JournalAmerican Review of Respiratory Disease
Volume131
Issue number3
StatePublished - 1985

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

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