Specific bronchoalveolar lavage IgG antibody in hypersensitivity pneumonitis from diphenylmethane diisocyanate

Rebecca Bascom, T. P. Kennedy, D. Levitz, C. R. Zeiss

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We evaluated a patient for dyspnea, fever, malaise, and hypoxemia that developed after exposure to diphenylmethane diisocyanate (MDI). Specific inhalation challenge with MDI caused fever, leukocytosis, a restrictive decline in forced vital capacity, and a decrease in Pa(O2) several hours after challenge. Bronchoalveolar lavage 24 h after challenge showed lymphocytic alveolitis. Specific IgG antibodies to MDI human serum albumin (MDI-HSA) conjugate were demonstrated in serum and bronchial lavage fluid using the enzyme-linked immunoabsorbent (ELISA) technique. These findings suggest participation of both humoral and cellular immunity in the pathogenesis of hypersensitivity pneumonitis from isocyanate exposure.

Original languageEnglish (US)
Pages (from-to)463-465
Number of pages3
JournalAmerican Review of Respiratory Disease
Volume131
Issue number3
StatePublished - 1985

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Extrinsic Allergic Alveolitis
Bronchoalveolar Lavage
Fever
Immunoglobulin G
Isocyanates
Antibodies
Leukocytosis
Vital Capacity
Bronchoalveolar Lavage Fluid
Humoral Immunity
Cellular Immunity
Serum Albumin
Dyspnea
Inhalation
Enzyme-Linked Immunosorbent Assay
Enzymes
Serum
4,4'-diphenylmethane diisocyanate
Hypoxia

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

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abstract = "We evaluated a patient for dyspnea, fever, malaise, and hypoxemia that developed after exposure to diphenylmethane diisocyanate (MDI). Specific inhalation challenge with MDI caused fever, leukocytosis, a restrictive decline in forced vital capacity, and a decrease in Pa(O2) several hours after challenge. Bronchoalveolar lavage 24 h after challenge showed lymphocytic alveolitis. Specific IgG antibodies to MDI human serum albumin (MDI-HSA) conjugate were demonstrated in serum and bronchial lavage fluid using the enzyme-linked immunoabsorbent (ELISA) technique. These findings suggest participation of both humoral and cellular immunity in the pathogenesis of hypersensitivity pneumonitis from isocyanate exposure.",
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Specific bronchoalveolar lavage IgG antibody in hypersensitivity pneumonitis from diphenylmethane diisocyanate. / Bascom, Rebecca; Kennedy, T. P.; Levitz, D.; Zeiss, C. R.

In: American Review of Respiratory Disease, Vol. 131, No. 3, 1985, p. 463-465.

Research output: Contribution to journalArticle

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