TY - JOUR
T1 - Specific sequence configurations of HIV-1 LTR G/C box array result in altered recruitment of Sp isoforms and correlate with disease progression
AU - Nonnemacher, Michael R.
AU - Irish, Bryan P.
AU - Liu, Yujie
AU - Mauger, David
AU - Wigdahl, Brian
N1 - Funding Information:
The authors would like to thank Dr. Tricia Burdo (Scripps Research Institute) for her advice. These studies were supported by the United States Public Health Service/National Institutes of Health (USPHS/NIH NS67768, NS32092, NS27415 awarded to B. Wigdahl).
PY - 2004/12
Y1 - 2004/12
N2 - Basal and activated human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) activity, and in return, viral replication is partly dependent on interactions of the G/C box array with the Sp family of transcription factors. Analysis of LTR Sp binding site sequence variants revealed a C-to-T change at position 5 within Sp site III that increased in frequency and a 5T mutation within Sp site II, which decreased in frequency during the course of HIV disease. These results suggest LTR Sp binding site sequence variants may prove useful as viral molecular markers indicative of progressive HIV-1-induced disease.
AB - Basal and activated human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) activity, and in return, viral replication is partly dependent on interactions of the G/C box array with the Sp family of transcription factors. Analysis of LTR Sp binding site sequence variants revealed a C-to-T change at position 5 within Sp site III that increased in frequency and a 5T mutation within Sp site II, which decreased in frequency during the course of HIV disease. These results suggest LTR Sp binding site sequence variants may prove useful as viral molecular markers indicative of progressive HIV-1-induced disease.
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U2 - 10.1016/j.jneuroim.2004.08.021
DO - 10.1016/j.jneuroim.2004.08.021
M3 - Article
C2 - 15579278
AN - SCOPUS:9644266837
SN - 0165-5728
VL - 157
SP - 39
EP - 47
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 1-2 SPEC. ISS.
ER -
