Spezifische serologische untersuchungen mit einem neuartigen authentischen HPV-antigen (Virus-like particles) auf HPV-6 antikorper bei gynakologischen patientenkollektiven

Translated title of the contribution: Specific serological testings with a novel authentic HPV antigen ivirus-like particles) for HPV-6 antibodies in gynecologic patient groups

K. Hehnd, N. D. Christensen, R. Höpfl, B. Wartttsch, A. Zeimer, C. Larcher, N. Ruth, A. Berganr, G. Pirscluter, M. R. Dierich, J. W. Kreider, O. Dapttnr

Research output: Contribution to journalArticle

Abstract

Objective: A serological assay lkw genital IIPV infection whould provide important additional information to HPV DNA diagnostic methods, since it would evaluate prior exposure to the viruses, detect significant systemic immunologic response to virus infection, and could he performed in most clinical laboratories. Methods: Serum samples from three groups of patients attending a gynecology clinic were analysed by direct ELISA for specific IgG-antibodies to baculovirus-expressed HPV-6-and BPV-1-L1-VLPs. Results: Positive IgG reactivity to HPV-6-L1-QIN were 4172 (6%) in a control group, 28/73 (38%) in a condyloma group and 17/62 (17%) in cervical intraepithelial neoplasia patients. Individual EgG ELISA values of condyloma and ON patients for HPV-6-L1-VLPs demonstrated no correlation to results with BPV-I-LI-VLPs. Conclusions: These data show that HPV-6-L1-VLPs are effective antigens for serological studies and can detect species specific antibodies with important implications for diagnosis. epidemiology. insites to natural course of disease. prognosis and evaluation of vaccination.

Translated title of the contributionSpecific serological testings with a novel authentic HPV antigen ivirus-like particles) for HPV-6 antibodies in gynecologic patient groups
Original languageGerman
Pages (from-to)25-31
Number of pages7
JournalGynakologisch-geburtshilfliche Rundschau
Volume35
DOIs
StatePublished - 1995

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

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