Spectral hole burning for ultrasound-modulated optical tomography of thick tissue

Xiao Xu, Sri-Rajasekhar Kothapalli, Honglin Liu, Lihong V. Wang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We apply spectral hole burning (SHB)-aided detection in ultrasound-modulated optical tomography (UOT) to image optical heterogeneities in thick tissue-mimicking phantom samples and chicken breast tissue. The efficiency of SHB is improved by using a Tm3+:YAG crystal of higher doping concentration (2.0-atomic%) and a double-pass pumping configuration, in which the pump beam is transmitted through the crystal twice to burn a deeper spectral hole with the available optical intensity. With the improved SHB-UOT system, we image absorbing, scattering, and phase objects that are embedded in the middle plane of a 30-mm-thick phantom sample. The imaging resolution was 0.5 mm in the lateral direction, as defined by the focal width of the ultrasonic transducer, and 1.5 mm in the axial direction, as determined by the ultrasonic burst length. We also image two absorbing objects embedded in a 32-mm-thick chicken breast sample. The results suggest that the improved SHB-UOT system is one step closer to the practical optical imaging application in biological and clinical studies.

Original languageEnglish (US)
Article number066018
JournalJournal of Biomedical Optics
Volume15
Issue number6
DOIs
StatePublished - Nov 1 2010

Fingerprint

Optical tomography
hole burning
tomography
Ultrasonics
Tissue
chickens
breast
ultrasonics
Imaging techniques
Crystals
Ultrasonic transducers
yttrium-aluminum garnet
crystals
bursts
transducers
pumping
Doping (additives)
Pumps
Scattering
pumps

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

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abstract = "We apply spectral hole burning (SHB)-aided detection in ultrasound-modulated optical tomography (UOT) to image optical heterogeneities in thick tissue-mimicking phantom samples and chicken breast tissue. The efficiency of SHB is improved by using a Tm3+:YAG crystal of higher doping concentration (2.0-atomic{\%}) and a double-pass pumping configuration, in which the pump beam is transmitted through the crystal twice to burn a deeper spectral hole with the available optical intensity. With the improved SHB-UOT system, we image absorbing, scattering, and phase objects that are embedded in the middle plane of a 30-mm-thick phantom sample. The imaging resolution was 0.5 mm in the lateral direction, as defined by the focal width of the ultrasonic transducer, and 1.5 mm in the axial direction, as determined by the ultrasonic burst length. We also image two absorbing objects embedded in a 32-mm-thick chicken breast sample. The results suggest that the improved SHB-UOT system is one step closer to the practical optical imaging application in biological and clinical studies.",
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Spectral hole burning for ultrasound-modulated optical tomography of thick tissue. / Xu, Xiao; Kothapalli, Sri-Rajasekhar; Liu, Honglin; Wang, Lihong V.

In: Journal of Biomedical Optics, Vol. 15, No. 6, 066018, 01.11.2010.

Research output: Contribution to journalArticle

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