Spectroscopically encoded resins for high throughput imaging time-of-flight secondary ion mass spectrometry

Sangki Chun, Jiyun Xu, Juan Cheng, Lunhan Ding, Nicholas Winograd, Hicham Fenniri

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Spectroscopic barcoding was recently introduced as a new pre-encoding strategy wherein the resin beads are not just carriers for solid phase synthesis, but are, in addition, the repository of the synthetic scheme to which they were subjected. To expand the repertoire of spectroscopically barcoded resins (BCRs), here we introduce a new family of halogenated polystyrene-based polymers designed for high-throughput combinatorial analysis using not only infrared and Raman spectroscopy but also imaging time-of-flight secondary ion mass spectrometry (ToF-SIMS). In particular, we have established that (a) the halogen content of these new resins can be used as an encoding element in quantitative imaging ToF-SIMS and (b) the number of styrene monomers used to generate unique vibrational fingerprints can be significantly reduced by using monomers in different molar ratios. The combination of quantitative imaging ToF-SIMS and vibrational spectroscopy is anticipated to dramatically increase the repertoire of possible BCRs from a few hundreds to several thousands.

Original languageEnglish (US)
Pages (from-to)18-25
Number of pages8
JournalJournal of Combinatorial Chemistry
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2006

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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