Spherical Nanoparticle Supported Lipid Bilayers for the Structural Study of Membrane Geometry-Sensitive Molecules

Riqiang Fu, Richard L. Gill, Edward Y. Kim, Nicole E. Briley, Erin R. Tyndall, Jie Xu, Conggang Li, Kumaran S. Ramamurthi, John M. Flanagan, Fang Tian

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Many essential cellular processes including endocytosis and vesicle trafficking require alteration of membrane geometry. These changes are usually mediated by proteins that can sense and/or induce membrane curvature. Using spherical nanoparticle supported lipid bilayers (SSLBs), we characterize how SpoVM, a bacterial development factor, interacts with differently curved membranes by magic angle spinning solid-state NMR. Our results demonstrate that SSLBs are an effective system for structural and topological studies of membrane geometry-sensitive molecules.

Original languageEnglish (US)
Pages (from-to)14031-14034
Number of pages4
JournalJournal of the American Chemical Society
Volume137
Issue number44
DOIs
StatePublished - Nov 11 2015

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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