Spherical Nanoparticle Supported Lipid Bilayers for the Structural Study of Membrane Geometry-Sensitive Molecules

Riqiang Fu, Richard L. Gill, Edward Y. Kim, Nicole E. Briley, Erin R. Tyndall, Jie Xu, Conggang Li, Kumaran S. Ramamurthi, John Flanagan, Fang Tian

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Many essential cellular processes including endocytosis and vesicle trafficking require alteration of membrane geometry. These changes are usually mediated by proteins that can sense and/or induce membrane curvature. Using spherical nanoparticle supported lipid bilayers (SSLBs), we characterize how SpoVM, a bacterial development factor, interacts with differently curved membranes by magic angle spinning solid-state NMR. Our results demonstrate that SSLBs are an effective system for structural and topological studies of membrane geometry-sensitive molecules.

Original languageEnglish (US)
Pages (from-to)14031-14034
Number of pages4
JournalJournal of the American Chemical Society
Volume137
Issue number44
DOIs
StatePublished - Nov 11 2015

Fingerprint

Lipid bilayers
Lipid Bilayers
Nanoparticles
Membranes
Molecules
Geometry
Magic angle spinning
Endocytosis
Nuclear magnetic resonance
Proteins

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Fu, Riqiang ; Gill, Richard L. ; Kim, Edward Y. ; Briley, Nicole E. ; Tyndall, Erin R. ; Xu, Jie ; Li, Conggang ; Ramamurthi, Kumaran S. ; Flanagan, John ; Tian, Fang. / Spherical Nanoparticle Supported Lipid Bilayers for the Structural Study of Membrane Geometry-Sensitive Molecules. In: Journal of the American Chemical Society. 2015 ; Vol. 137, No. 44. pp. 14031-14034.
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Spherical Nanoparticle Supported Lipid Bilayers for the Structural Study of Membrane Geometry-Sensitive Molecules. / Fu, Riqiang; Gill, Richard L.; Kim, Edward Y.; Briley, Nicole E.; Tyndall, Erin R.; Xu, Jie; Li, Conggang; Ramamurthi, Kumaran S.; Flanagan, John; Tian, Fang.

In: Journal of the American Chemical Society, Vol. 137, No. 44, 11.11.2015, p. 14031-14034.

Research output: Contribution to journalArticle

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