Splenic angiosarcoma: A clinicopathologic and immunophenotypic study of 28 cases

Thomas S. Neuhauser, Gregory A. Derringer, Lester D.R. Thompson, Julie C. Fanburg-Smith, Markku Miettinen, Anne Saaristo, Susan L. Abbondanzo

Research output: Contribution to journalArticle

109 Scopus citations

Abstract

Primary angiosarcoma of the spleen is a rare neoplasm that has not been well characterized. We describe the clinical, morphologic, and immunophenotypic findings of 28 cases of primary splenic angiosarcoma, including one case that shares features of lymphangloma/lymphangiosarcoma. The patients included 16 men and 12 women, aged 29 to 85 years, with a mean of 59 years and median of 63 years. The majority of parents (75%) complained of abdominal pain, and 25% presented with splenic rupture. The most common physical finding was splenomegaly (71%). Seventeen of 21 patients were reported to have anemia. Macroscopic examination showed splenomegaly in 85% cases. Sectioning revealed discrete lesions in 88% of cases, ranging from well-circumscribed firm nodules to poorly delineated foci of necrosis and hemorrhage associated with cystic spaces. Microscopically, the tumors were heterogenous; however, all cases demonstrated at least a focal vasoformative component lined by atypical endothelial cells. Solid sarcomatous, papillary, and epithelioid growth patterns were observed. The solid sarcomatous component resembled fibrosarcoma in two cases and malignant fibrous-bistlocytoma in one case. Hemorrhage, necrosis, hemosiderin, extramedullary hematopoiesis, and intracytoplasmic hyaline globules were frequently identified. A panel of immunohistochemical studies revealed that the majority of minors were immunoreactive for at least two markers of vascular differentiation (CD34, FVIIIRAg, VEGFR3, and CD31) and at least one marker of histiocytic differentiation (CD68 and/or lysozyme). Metastases developed in 100% of patients during the course of their disease. Twenty-six patients died of disease despite aggressive therapy, whereas only two patients are alive at last follow-up, one with disease at 8 years and the other without disease at 10 years. In conclusion, primary splenic angiosarcoma is an extremely aggressive neoplasm that is almost universally fatal. The majority of splenic angiosarcomas coexpress histiocytic and endothelial markers by immunohistocbemical analysis, which suggest that some tumors may originate from splenic lining cells.

Original languageEnglish (US)
Pages (from-to)978-987
Number of pages10
JournalModern Pathology
Volume13
Issue number9
DOIs
StatePublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Splenic angiosarcoma: A clinicopathologic and immunophenotypic study of 28 cases'. Together they form a unique fingerprint.

  • Cite this

    Neuhauser, T. S., Derringer, G. A., Thompson, L. D. R., Fanburg-Smith, J. C., Miettinen, M., Saaristo, A., & Abbondanzo, S. L. (2000). Splenic angiosarcoma: A clinicopathologic and immunophenotypic study of 28 cases. Modern Pathology, 13(9), 978-987. https://doi.org/10.1038/modpathol.3880178