Spontaneous deciduosarcoma in a domestic rabbit (Oryctolagus cuniculus)

Timothy Cooper, D. Adelsohn, S. R. Gilbertson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Deciduosarcoma is a rare, hormonally dependent neoplasm with features of malignancy, previously reported only in rabbits enrolled in chronic toxicology studies involving estrogens with or without progestins. An exploratory laparotomy was performed on a 6-year-old pet Dutch dwarf rabbit following palpation of a 6-cm-diameter abdominal mass. Grossly, the mass was fleshy and nodular, adhered to but not appearing to originate from the small intestine, with a smaller mass of similar appearance involving the uterus, and an effaced mesenteric lymph node. Histologically, the mass was characterized by spindloid cells and large epithelioid cells with abundant pale eosinophilic vacuolated cytoplasm and an infiltrative pattern of growth. Giant cells with large, bizarre, hyperchromatic nuclei were common. Cells were positive by immunohistochemistry for vimentin and progesterone and estrogen receptors and negative for pancytokeratin (AE1/AE3), cytokeratin 18, desmin, alpha-smooth muscle actin (SMA), and CD10. Based on histologic and immunohistochemical findings, a diagnosis of deciduosarcoma was made.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalVeterinary Pathology
Volume43
Issue number3
DOIs
StatePublished - May 1 2006

Fingerprint

Oryctolagus cuniculus
rabbits
Rabbits
Keratin-18
Epithelioid Cells
Desmin
Palpation
Pets
Vimentin
Progestins
Progesterone Receptors
Giant Cells
Estrogen Receptors
Toxicology
Laparotomy
Small Intestine
Uterus
Smooth Muscle
Actins
Neoplasms

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Cooper, Timothy ; Adelsohn, D. ; Gilbertson, S. R. / Spontaneous deciduosarcoma in a domestic rabbit (Oryctolagus cuniculus). In: Veterinary Pathology. 2006 ; Vol. 43, No. 3. pp. 377-380.
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Spontaneous deciduosarcoma in a domestic rabbit (Oryctolagus cuniculus). / Cooper, Timothy; Adelsohn, D.; Gilbertson, S. R.

In: Veterinary Pathology, Vol. 43, No. 3, 01.05.2006, p. 377-380.

Research output: Contribution to journalArticle

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