Spontaneous deciduosarcoma in a domestic rabbit (Oryctolagus cuniculus)

T. K. Cooper, D. Adelsohn, S. R. Gilbertson

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Deciduosarcoma is a rare, hormonally dependent neoplasm with features of malignancy, previously reported only in rabbits enrolled in chronic toxicology studies involving estrogens with or without progestins. An exploratory laparotomy was performed on a 6-year-old pet Dutch dwarf rabbit following palpation of a 6-cm-diameter abdominal mass. Grossly, the mass was fleshy and nodular, adhered to but not appearing to originate from the small intestine, with a smaller mass of similar appearance involving the uterus, and an effaced mesenteric lymph node. Histologically, the mass was characterized by spindloid cells and large epithelioid cells with abundant pale eosinophilic vacuolated cytoplasm and an infiltrative pattern of growth. Giant cells with large, bizarre, hyperchromatic nuclei were common. Cells were positive by immunohistochemistry for vimentin and progesterone and estrogen receptors and negative for pancytokeratin (AE1/AE3), cytokeratin 18, desmin, alpha-smooth muscle actin (SMA), and CD10. Based on histologic and immunohistochemical findings, a diagnosis of deciduosarcoma was made.

Original languageEnglish (US)
Pages (from-to)377-380
Number of pages4
JournalVeterinary Pathology
Volume43
Issue number3
DOIs
StatePublished - May 2006

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Fingerprint Dive into the research topics of 'Spontaneous deciduosarcoma in a domestic rabbit (Oryctolagus cuniculus)'. Together they form a unique fingerprint.

Cite this