Spontaneous germinal centers and autoimmunity

Phillip P. Domeier, Stephanie L. Schell, Ziaur S.M. Rahman

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Germinal centers (GCs) are dynamic microenvironments that form in the secondary lymphoid organs and generate somatically mutated high-affinity antibodies necessary to establish an effective humoral immune response. Tight regulation of GC responses is critical for maintaining self-tolerance. GCs can arise in the absence of purposeful immunization or overt infection (called spontaneous GCs, Spt-GCs). In autoimmune-prone mice and patients with autoimmune disease, aberrant regulation of Spt-GCs is thought to promote the development of somatically mutated pathogenic autoantibodies and the subsequent development of autoimmunity. The mechanisms that control the formation of Spt-GCs and promote systemic autoimmune diseases remain an open question and the focus of ongoing studies. Here, we discuss the most current studies on the role of Spt-GCs in autoimmunity.

Original languageEnglish (US)
Pages (from-to)4-18
Number of pages15
JournalAutoimmunity
Volume50
Issue number1
DOIs
StatePublished - Jan 2 2017

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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