Spontaneous germinal centers and autoimmunity

Phillip P. Domeier, Stephanie L. Schell, Ziaur S.M. Rahman

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Germinal centers (GCs) are dynamic microenvironments that form in the secondary lymphoid organs and generate somatically mutated high-affinity antibodies necessary to establish an effective humoral immune response. Tight regulation of GC responses is critical for maintaining self-tolerance. GCs can arise in the absence of purposeful immunization or overt infection (called spontaneous GCs, Spt-GCs). In autoimmune-prone mice and patients with autoimmune disease, aberrant regulation of Spt-GCs is thought to promote the development of somatically mutated pathogenic autoantibodies and the subsequent development of autoimmunity. The mechanisms that control the formation of Spt-GCs and promote systemic autoimmune diseases remain an open question and the focus of ongoing studies. Here, we discuss the most current studies on the role of Spt-GCs in autoimmunity.

Original languageEnglish (US)
Pages (from-to)4-18
Number of pages15
JournalAutoimmunity
Volume50
Issue number1
DOIs
StatePublished - Jan 2 2017

Fingerprint

Germinal Center
Autoimmunity
Autoimmune Diseases
Self Tolerance
Antibody Affinity
Humoral Immunity
Autoantibodies
Immunization
Infection

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Domeier, Phillip P. ; Schell, Stephanie L. ; Rahman, Ziaur S.M. / Spontaneous germinal centers and autoimmunity. In: Autoimmunity. 2017 ; Vol. 50, No. 1. pp. 4-18.
@article{3a21892acacb4147956b61a68a495806,
title = "Spontaneous germinal centers and autoimmunity",
abstract = "Germinal centers (GCs) are dynamic microenvironments that form in the secondary lymphoid organs and generate somatically mutated high-affinity antibodies necessary to establish an effective humoral immune response. Tight regulation of GC responses is critical for maintaining self-tolerance. GCs can arise in the absence of purposeful immunization or overt infection (called spontaneous GCs, Spt-GCs). In autoimmune-prone mice and patients with autoimmune disease, aberrant regulation of Spt-GCs is thought to promote the development of somatically mutated pathogenic autoantibodies and the subsequent development of autoimmunity. The mechanisms that control the formation of Spt-GCs and promote systemic autoimmune diseases remain an open question and the focus of ongoing studies. Here, we discuss the most current studies on the role of Spt-GCs in autoimmunity.",
author = "Domeier, {Phillip P.} and Schell, {Stephanie L.} and Rahman, {Ziaur S.M.}",
year = "2017",
month = "1",
day = "2",
doi = "10.1080/08916934.2017.1280671",
language = "English (US)",
volume = "50",
pages = "4--18",
journal = "Autoimmunity",
issn = "0891-6934",
publisher = "Informa Healthcare",
number = "1",

}

Spontaneous germinal centers and autoimmunity. / Domeier, Phillip P.; Schell, Stephanie L.; Rahman, Ziaur S.M.

In: Autoimmunity, Vol. 50, No. 1, 02.01.2017, p. 4-18.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Spontaneous germinal centers and autoimmunity

AU - Domeier, Phillip P.

AU - Schell, Stephanie L.

AU - Rahman, Ziaur S.M.

PY - 2017/1/2

Y1 - 2017/1/2

N2 - Germinal centers (GCs) are dynamic microenvironments that form in the secondary lymphoid organs and generate somatically mutated high-affinity antibodies necessary to establish an effective humoral immune response. Tight regulation of GC responses is critical for maintaining self-tolerance. GCs can arise in the absence of purposeful immunization or overt infection (called spontaneous GCs, Spt-GCs). In autoimmune-prone mice and patients with autoimmune disease, aberrant regulation of Spt-GCs is thought to promote the development of somatically mutated pathogenic autoantibodies and the subsequent development of autoimmunity. The mechanisms that control the formation of Spt-GCs and promote systemic autoimmune diseases remain an open question and the focus of ongoing studies. Here, we discuss the most current studies on the role of Spt-GCs in autoimmunity.

AB - Germinal centers (GCs) are dynamic microenvironments that form in the secondary lymphoid organs and generate somatically mutated high-affinity antibodies necessary to establish an effective humoral immune response. Tight regulation of GC responses is critical for maintaining self-tolerance. GCs can arise in the absence of purposeful immunization or overt infection (called spontaneous GCs, Spt-GCs). In autoimmune-prone mice and patients with autoimmune disease, aberrant regulation of Spt-GCs is thought to promote the development of somatically mutated pathogenic autoantibodies and the subsequent development of autoimmunity. The mechanisms that control the formation of Spt-GCs and promote systemic autoimmune diseases remain an open question and the focus of ongoing studies. Here, we discuss the most current studies on the role of Spt-GCs in autoimmunity.

UR - http://www.scopus.com/inward/record.url?scp=85011827031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011827031&partnerID=8YFLogxK

U2 - 10.1080/08916934.2017.1280671

DO - 10.1080/08916934.2017.1280671

M3 - Review article

C2 - 28166685

AN - SCOPUS:85011827031

VL - 50

SP - 4

EP - 18

JO - Autoimmunity

JF - Autoimmunity

SN - 0891-6934

IS - 1

ER -