Squamous cell carcinoma of the lip is rarely seen in children. We present the case of a 19-month-old child, without known risk factors, who developed invasive squamous cell carcinoma involving the skin and underlying muscle of the lip. The histology of the tumor was invasive squamous cell carcinoma of the keratoacanthoma type. The distinction between this lesion and keratoacanthoma is often difficult and rests on the findings of invasion and significant atypia. Due to the extremely low incidence of squamous cell carcinoma in children, there are few therapeutic guidelines pertaining specifically to infants or children. This patient underwent wide local excision as definitive treatment. Currently, it is 24 months after excision of the tumor and he remains free of clinical recurrence.
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