Square Biphasic Pulse Deep Brain Stimulation for Parkinson’s Disease: The BiP-PD Study

Sol De Jesus, Michael S. Okun, Kelly D. Foote, Daniel Martinez-Ramirez, Jaimie A. Roper, Chris J. Hass, Leili Shahgholi, Umer Akbar, Aparna Wagle Shukla, Robert S. Raike, Leonardo Almeida

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: Conventional Parkinson’s disease (PD) deep brain stimulation (DBS) utilizes a pulse with an active phase and a passive charge-balancing phase. A pulse-shaping strategy that eliminates the passive phase may be a promising approach to addressing movement disorders. Objectives: The current study assessed the safety and tolerability of square biphasic pulse shaping (sqBIP) DBS for use in PD. Methods: This small pilot safety and tolerability study compared sqBiP versus conventional DBS. Nine were enrolled. The safety and tolerability were assessed over a 3-h period on sqBiP. Friedman’s test compared blinded assessments at baseline, washout, and 30 min, 1 h, 2 h, and 3 h post sqBIP. Results: Biphasic pulses were safe and well tolerated by all participants. SqBiP performed as well as conventional DBS without significant differences in motor scores nor accelerometer or gait measures. Conclusion: Biphasic pulses were well-tolerated and provided similar benefit to conventional DBS. Further studies should address effectiveness of sqBIP in select PD patients.

Original languageEnglish (US)
Article number368
JournalFrontiers in Human Neuroscience
Volume13
DOIs
StatePublished - Oct 17 2019

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Behavioral Neuroscience

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