TY - JOUR
T1 - Stability of opioid growth factor ([Met5]-enkephalin) in solution using HPLC and photodiode array detection
AU - Hurst, W. Jeffrey
AU - McLaughlin, Patricia J.
AU - Zagon, Ian S.
AU - Rogosnitzky, Moshe
PY - 2006/1/1
Y1 - 2006/1/1
N2 - A reversed phased HPLC method with photodiode array detection was used to monitor the stability of opioid growth factor (OGF; [Met5]- enkephalin) in sterile saline for 1, 2, and 8 weeks, and stored at -17°C, 4°C, and 23°C. Samples maintained at -17°C had 97% of the initial OGF concentration after 2 months, whereas those stored at 4°C had 94% of the original concentration. Preparations housed at 22°C had reductions of 6-12% by the 8th week. These data provide important information about storage of OGF for clinical applications.
AB - A reversed phased HPLC method with photodiode array detection was used to monitor the stability of opioid growth factor (OGF; [Met5]- enkephalin) in sterile saline for 1, 2, and 8 weeks, and stored at -17°C, 4°C, and 23°C. Samples maintained at -17°C had 97% of the initial OGF concentration after 2 months, whereas those stored at 4°C had 94% of the original concentration. Preparations housed at 22°C had reductions of 6-12% by the 8th week. These data provide important information about storage of OGF for clinical applications.
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U2 - 10.1080/10826070500416395
DO - 10.1080/10826070500416395
M3 - Article
AN - SCOPUS:33644527294
VL - 29
SP - 151
EP - 157
JO - Journal of Liquid Chromatography and Related Technologies
JF - Journal of Liquid Chromatography and Related Technologies
SN - 1082-6076
IS - 2
ER -