Stabilization of dendritic arbor structure in vivo by CaMKII

Gangyi Wu, Hollis T. Cline

Research output: Contribution to journalArticle

303 Citations (Scopus)

Abstract

Calcium-calmodulin-dependent protein kinase II (CaMKII) promotes the maturation of retinotectal glutamatergic synapses in Xenopus. Whether CaMKII activity also controls morphological maturation of optic tectal neurons was tested using in vivo time-lapse imaging of single neurons over periods of up to 5 days. Dendritic arbor elaboration slows with maturation, in correlation with the onset of CaMKII expression. Elevating CaMKII activity in young neurons by viral expression of constitutively active CaMKII slowed dendritic growth to a rate comparable to that of mature neurons. CaMKII overexpression stabilized dendritic structure in more mature neurons, whereas CaMKII inhibition increased their dendritic growth. Thus, endogenous CaMKII activity limits dendritic growth and stabilizes dendrites, and it may act as an activity-dependent mediator of neuronal maturation.

Original languageEnglish (US)
Pages (from-to)222-226
Number of pages5
JournalScience
Volume279
Issue number5348
DOIs
StatePublished - Jan 9 1998

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Calcium-Calmodulin-Dependent Protein Kinase Type 2
Neurons
Growth
Time-Lapse Imaging
Calcium-Calmodulin-Dependent Protein Kinases
Dendrites
Xenopus
Synapses

All Science Journal Classification (ASJC) codes

  • General

Cite this

Wu, Gangyi ; Cline, Hollis T. / Stabilization of dendritic arbor structure in vivo by CaMKII. In: Science. 1998 ; Vol. 279, No. 5348. pp. 222-226.
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Stabilization of dendritic arbor structure in vivo by CaMKII. / Wu, Gangyi; Cline, Hollis T.

In: Science, Vol. 279, No. 5348, 09.01.1998, p. 222-226.

Research output: Contribution to journalArticle

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