Stable isotope dilution techniques for assessing vitamin A status and bioefficacy of provitamin A carotenoids in humans

Harold C. Furr, Michael H. Green, Marjorie Haskell, Najat Mokhtar, Penelope Nestel, Sam Newton, Judy D. Ribaya-Mercado, Guangwen Tang, Sherry Tanumihardjo, Emorn Wasantwisut

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations

Abstract

Vitamin A deficiency is a major global public health problem. Among the variety of techniques that are available for assessing human vitamin A status, evaluating the provitamin A nutritional values of foodstuffs and estimating human vitamin A requirements, isotope dilution provides the most accurate estimates. Although the relative expense of isotope dilution restricts its applications, it has an important function as the standard of reference for other techniques. Mathematical modelling plays an indispensable role in the interpretation of isotope dilution data. This review summarises recent applications of stable isotope methodology to determine human vitamin A status, estimate human vitamin A requirements, and calculate the bioconversion and bioefficacy of food carotenoids.

Original languageEnglish (US)
Pages (from-to)596-607
Number of pages12
JournalPublic Health Nutrition
Volume8
Issue number6
DOIs
StatePublished - Sep 2005

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

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