Stable phantoms for characterization of photoacoustic tomography (PAT) systems

Sarah E. Bohndiek, Dominique Van De Sompel, Sandhya Bodapati, Sri-Rajasekhar Kothapalli, Sanjiv S. Gambhir

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Photoacoustic tomography (PAT) is an emerging modality that combines the high contrast of optical imaging, with the spatial resolution and penetration depth of ultrasound, by exploiting the photoacoustic effect. As with any new imaging modality, reliable physical phantoms are needed to: calibrate instruments; validate performance; optimize signal-to-noise; perform routine quality control; and compare systems. Phantom materials for testing small animal PAT systems should also mimic both the optical and acoustic properties of soft tissue, while for calibration purposes should be resistant to degradation over long time periods. We show here that polyvinyl chloride plastisol (PVCP) phantoms enable calibration and performance validation using two PAT systems with distinct designs (Visualsonics Vevo LAZR and Endra Nexus 128) across a wavelength range of 680 nm - 950 nm. Inclusions between 2 and 3.2 mm in diameter were fabricated from PVCP using a range of dye concentrations (0 % to 0.256 % Black Plastic Color, BPC) in a custom mold. A calibration phantom was imaged repeatedly on both systems, over time scales of minutes, hours and days, to assess system stability. Both systems demonstrated good reproducibility over time, with the coefficient of variation in the measured signal-to-noise ratio (SNR) being less than 15% over the course of 30 days. Imaging performance was optimized by plotting SNR as a function of different system parameters. The visualization of objects embedded in optically absorbing and scattering backgrounds was also assessed. PVCP is easy to work with and provides stable phantoms for assessing PAT system performance.

Original languageEnglish (US)
Title of host publicationDesign and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V
Volume8583
DOIs
StatePublished - May 28 2013
EventDesign and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V - San Francisco, CA, United States
Duration: Feb 2 2013Feb 3 2013

Other

OtherDesign and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V
CountryUnited States
CitySan Francisco, CA
Period2/2/132/3/13

Fingerprint

plastisols
Photoacoustic effect
polyvinyl chloride
Tomography
Plastisols
tomography
Polyvinyl Chloride
Calibration
Polyvinyl chlorides
Signal-To-Noise Ratio
signal to noise ratios
Imaging techniques
Signal to noise ratio
Materials Testing
systems stability
acoustic properties
plotting
Optical Imaging
quality control
Acoustic properties

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Bohndiek, S. E., Van De Sompel, D., Bodapati, S., Kothapalli, S-R., & Gambhir, S. S. (2013). Stable phantoms for characterization of photoacoustic tomography (PAT) systems. In Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V (Vol. 8583). [858308] https://doi.org/10.1117/12.2005195
Bohndiek, Sarah E. ; Van De Sompel, Dominique ; Bodapati, Sandhya ; Kothapalli, Sri-Rajasekhar ; Gambhir, Sanjiv S. / Stable phantoms for characterization of photoacoustic tomography (PAT) systems. Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V. Vol. 8583 2013.
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abstract = "Photoacoustic tomography (PAT) is an emerging modality that combines the high contrast of optical imaging, with the spatial resolution and penetration depth of ultrasound, by exploiting the photoacoustic effect. As with any new imaging modality, reliable physical phantoms are needed to: calibrate instruments; validate performance; optimize signal-to-noise; perform routine quality control; and compare systems. Phantom materials for testing small animal PAT systems should also mimic both the optical and acoustic properties of soft tissue, while for calibration purposes should be resistant to degradation over long time periods. We show here that polyvinyl chloride plastisol (PVCP) phantoms enable calibration and performance validation using two PAT systems with distinct designs (Visualsonics Vevo LAZR and Endra Nexus 128) across a wavelength range of 680 nm - 950 nm. Inclusions between 2 and 3.2 mm in diameter were fabricated from PVCP using a range of dye concentrations (0 {\%} to 0.256 {\%} Black Plastic Color, BPC) in a custom mold. A calibration phantom was imaged repeatedly on both systems, over time scales of minutes, hours and days, to assess system stability. Both systems demonstrated good reproducibility over time, with the coefficient of variation in the measured signal-to-noise ratio (SNR) being less than 15{\%} over the course of 30 days. Imaging performance was optimized by plotting SNR as a function of different system parameters. The visualization of objects embedded in optically absorbing and scattering backgrounds was also assessed. PVCP is easy to work with and provides stable phantoms for assessing PAT system performance.",
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Bohndiek, SE, Van De Sompel, D, Bodapati, S, Kothapalli, S-R & Gambhir, SS 2013, Stable phantoms for characterization of photoacoustic tomography (PAT) systems. in Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V. vol. 8583, 858308, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V, San Francisco, CA, United States, 2/2/13. https://doi.org/10.1117/12.2005195

Stable phantoms for characterization of photoacoustic tomography (PAT) systems. / Bohndiek, Sarah E.; Van De Sompel, Dominique; Bodapati, Sandhya; Kothapalli, Sri-Rajasekhar; Gambhir, Sanjiv S.

Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V. Vol. 8583 2013. 858308.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Bohndiek SE, Van De Sompel D, Bodapati S, Kothapalli S-R, Gambhir SS. Stable phantoms for characterization of photoacoustic tomography (PAT) systems. In Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V. Vol. 8583. 2013. 858308 https://doi.org/10.1117/12.2005195