Stage-structured transmission of phocine distemper virus in the Dutch 2002 outbreak

Petra Klepac, Laura W. Pomeroy, Ottar N. Bjornstad, Thijs Kuiken, Albert D.M.E. Osterhaus, Jolianne M. Rijks

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Heterogeneities in transmission among hosts can be very important in shaping infectious disease dynamics. In mammals with strong social organization, such heterogeneities are often structured by functional stage: juveniles, subadults and adults. We investigate the importance of such stage-related heterogeneities in shaping the 2002 phocine distemper virus (PDV) outbreak in the Dutch Wadden Sea, when more than 40 per cent of the harbour seals were killed. We do this by comparing the statistical fit of a hierarchy of models with varying transmission complexity: homogeneous versus heterogeneous mixing and densityversus frequency-dependent transmission. We use the stranding data as a proxy for incidence and use Poisson likelihoods to estimate the 'who acquires infection from whom' (WAIFW) matrix. Statistically, the model with strong heterogeneous mixing and density-dependent transmission was found to best describe the transmission dynamics. However, patterns of incidence support a model of frequency-dependent transmission among adults and juveniles. Based on the maximum-likelihood WAIFW matrix estimates, we use the next-generation formalism to calculate an R 0 between 2 and 2.5 for the Dutch 2002 PDV epidemic.

Original languageEnglish (US)
Pages (from-to)2469-2476
Number of pages8
JournalProceedings of the Royal Society B: Biological Sciences
Volume276
Issue number1666
DOIs
StatePublished - Jul 7 2009

Fingerprint

Phocine Distemper Virus
Phocine distemper virus
Viruses
Disease Outbreaks
virus
Phoca
angle of incidence
Incidence
Proxy
Infection
Oceans and Seas
Communicable Diseases
stranding
Mammals
Phoca vitulina
matrix
social organization
infectious disease
social structure
North Sea

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Klepac, Petra ; Pomeroy, Laura W. ; Bjornstad, Ottar N. ; Kuiken, Thijs ; Osterhaus, Albert D.M.E. ; Rijks, Jolianne M. / Stage-structured transmission of phocine distemper virus in the Dutch 2002 outbreak. In: Proceedings of the Royal Society B: Biological Sciences. 2009 ; Vol. 276, No. 1666. pp. 2469-2476.
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Stage-structured transmission of phocine distemper virus in the Dutch 2002 outbreak. / Klepac, Petra; Pomeroy, Laura W.; Bjornstad, Ottar N.; Kuiken, Thijs; Osterhaus, Albert D.M.E.; Rijks, Jolianne M.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 276, No. 1666, 07.07.2009, p. 2469-2476.

Research output: Contribution to journalArticle

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