Statistical model for characterizing epistatic control of triploid endosperm triggered by maternal and offspring QTLs

Yuehua Cui, Rongling Wu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To study the effects of maternal and endosperm quantitative trait locus (QTL) interaction on endosperm development, we derive a two-stage hierarchical statistical model within the maximum-likelihood context, implemented with an expectation-maximization algorithm. A model incorporating both maternal and offspring marker information can improve the accuracy and precision of genetic mapping. Extensive simulations under different sampling strategies, heritability levels and gene action modes were performed to investigate the statistical properties of the model. The QTL location and parameters are better estimated when two QTLs are located at different intervals than when they are located at the same interval. Also, the additive effect of the offspring QTLs is better estimated than the additive effect of the maternal QTLs. The implications of our model for agricultural and evolutionary genetic research are discussed.

Original languageEnglish (US)
Pages (from-to)65-75
Number of pages11
JournalGenetical research
Volume86
Issue number1
DOIs
StatePublished - Aug 1 2005

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Triploidy
Endosperm
Statistical Models
Quantitative Trait Loci
Mothers
Genetic Research
Genes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

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abstract = "To study the effects of maternal and endosperm quantitative trait locus (QTL) interaction on endosperm development, we derive a two-stage hierarchical statistical model within the maximum-likelihood context, implemented with an expectation-maximization algorithm. A model incorporating both maternal and offspring marker information can improve the accuracy and precision of genetic mapping. Extensive simulations under different sampling strategies, heritability levels and gene action modes were performed to investigate the statistical properties of the model. The QTL location and parameters are better estimated when two QTLs are located at different intervals than when they are located at the same interval. Also, the additive effect of the offspring QTLs is better estimated than the additive effect of the maternal QTLs. The implications of our model for agricultural and evolutionary genetic research are discussed.",
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Statistical model for characterizing epistatic control of triploid endosperm triggered by maternal and offspring QTLs. / Cui, Yuehua; Wu, Rongling.

In: Genetical research, Vol. 86, No. 1, 01.08.2005, p. 65-75.

Research output: Contribution to journalArticle

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