Stereoselective pharmacological effects of lysergic acid amides possessing chirality in the amide substituent

David E. Nichols, A. Monte, X. Huang, D. Marona-Lewicka

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Abstract

Studies of the affinities for serotonin 5-HT2A and 5-HT1A receptor subtypes of lysergic acid amides prepared from chiral 2-aminoalkanes showed a stereoselective preference at both receptor types for the amides with alkyl groups containing the R configuration. The 5-HT2A receptor was less tolerant of long alkyl groups than was the 5-HT1A subtype. In vivo assays in rats trained to discriminate LSD from saline also showed that amides with alkyl groups having the R configuration were most potent.

Original languageEnglish (US)
Pages (from-to)117-119
Number of pages3
JournalBehavioural Brain Research
Volume73
Issue number1-2
DOIs
StatePublished - Dec 15 1995

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All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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