Stereospecific modulation of tumorigenicity by opioid antagonists

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Abstract

The effects of (+) and (-) isomers of naloxone in altering tumor response in A/Jax mice inoculated with S20Y neuroblastoma were determined. Mice given daily subcutaneous injections of 15 mg/kg (-)naloxone had a 71% tumor incidence, a 33% delay in the time before tumor appearance, and a 28% increase in survival time. Inoculation of neuroblastoma cells in control subjects resulted in 100% tumor incidence within 13 days. Animals given 15 mg/kg (+)naloxone were comparable to control subjects in all aspects of neural neoplasia. These results show that opioid antagonists exert a stereospecific action on neural cancers, and provide further evidence that endogenous opioid systems play an important role in neuro-oncogenic expression.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalEuropean Journal of Pharmacology
Volume113
Issue number1
DOIs
Publication statusPublished - Jul 11 1985

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All Science Journal Classification (ASJC) codes

  • Pharmacology

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