Stereotactic radiosurgery for intracranial meningiomas: Current concepts and future perspectives

Alireza Mansouri, Daipayan Guha, George Klironomos, Soroush Larjani, Gelareh Zadeh, Douglas Kondziolka

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Meningiomas are among the most common adult brain tumors. Although the optimal management of meningiomas would provide complete elimination of the lesion, this cannot always be accomplished safely through resection. Therefore, other therapeutic modalities, such as stereotactic radiosurgery (as primary or adjunctive therapy), have emerged. In the current review, we have provided an overview of the historical outcomes of various radiosurgical modalities applied in the management of meningiomas. Furthermore, we provide a discussion on key factors (eg World Health Organization grade, lesion size, and lesion location) that affect tumor control and adverse event rates. We discuss recent changes in our understanding of meningiomas, based on molecular and genetic markers, and how these will change our perspective on the management of meningiomas. We conclude by outlining the areas in which knowledge gaps persist and provide suggestions as to how these can be addressed.

Original languageEnglish (US)
Pages (from-to)362-371
Number of pages10
JournalNeurosurgery
Volume76
Issue number4
DOIs
StatePublished - Apr 19 2015

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Radiosurgery
Meningioma
Genetic Markers
Brain Neoplasms
Molecular Biology
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Mansouri, Alireza ; Guha, Daipayan ; Klironomos, George ; Larjani, Soroush ; Zadeh, Gelareh ; Kondziolka, Douglas. / Stereotactic radiosurgery for intracranial meningiomas : Current concepts and future perspectives. In: Neurosurgery. 2015 ; Vol. 76, No. 4. pp. 362-371.
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Stereotactic radiosurgery for intracranial meningiomas : Current concepts and future perspectives. / Mansouri, Alireza; Guha, Daipayan; Klironomos, George; Larjani, Soroush; Zadeh, Gelareh; Kondziolka, Douglas.

In: Neurosurgery, Vol. 76, No. 4, 19.04.2015, p. 362-371.

Research output: Contribution to journalReview article

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AU - Mansouri, Alireza

AU - Guha, Daipayan

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AU - Zadeh, Gelareh

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