Steroids alone or as adjunctive therapy with doxycycline fail to improve oviduct damage in mice infected with Chlamydia muridarum

Tammy E. Corr, Jeanne Sullivan, Lauren C. Frazer, Charles W. Andrews, Catherine M. O'Connell, Toni Darville

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In women, Chlamydia trachomatis can ascend from the cervix to the fallopian tubes, where an overly aggressive host inflammatory response can cause scarring that leads to chronic pelvic pain, infertility, or ectopic pregnancy. Although screening and treatment programs for women have resulted in decreased rates of sequelae, morbidities associated with oviduct scarring continue to occur. Since corticosteroids have anti-inflammatory and antifibrotic effects, we tested the ability of dexamethasone to inhibit inflammation and prevent oviduct scarring in mice genitally infected with Chlamydia muridarum. The administration of 1 or 2.5 mg/kg of body weight of dexamethasone on days 7 to 21 of infection resulted in reduced accumulation of inflammatory cells in the oviducts compared to that in controls. However, a concomitant increase in bacterial burden was observed, and chronic oviduct disease was not reduced. Adjunctive administration of a prolonged (21-day) or short (3-day) course of dexamethasone in combination with the antibiotic doxycycline also failed to reduce chronic oviduct pathology compared to antibiotic treatment alone. Steroids administered alone or adjunctively with antibiotics failed to prevent oviduct damage in this murine model of C. trachomatis infection.

Original languageEnglish (US)
Pages (from-to)824-830
Number of pages7
JournalClinical and Vaccine Immunology
Volume21
Issue number6
DOIs
StatePublished - Jun 2014

Fingerprint

Chlamydia muridarum
Oviducts
Doxycycline
Dexamethasone
Steroids
Anti-Bacterial Agents
Cicatrix
Chlamydia trachomatis
Pathology
Adrenal Cortex Hormones
Screening
Anti-Inflammatory Agents
Therapeutics
Cells
Chlamydia Infections
Pelvic Pain
Fallopian Tubes
Ectopic Pregnancy
Cervix Uteri
Chronic Pain

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

Cite this

Corr, Tammy E. ; Sullivan, Jeanne ; Frazer, Lauren C. ; Andrews, Charles W. ; O'Connell, Catherine M. ; Darville, Toni. / Steroids alone or as adjunctive therapy with doxycycline fail to improve oviduct damage in mice infected with Chlamydia muridarum. In: Clinical and Vaccine Immunology. 2014 ; Vol. 21, No. 6. pp. 824-830.
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Steroids alone or as adjunctive therapy with doxycycline fail to improve oviduct damage in mice infected with Chlamydia muridarum. / Corr, Tammy E.; Sullivan, Jeanne; Frazer, Lauren C.; Andrews, Charles W.; O'Connell, Catherine M.; Darville, Toni.

In: Clinical and Vaccine Immunology, Vol. 21, No. 6, 06.2014, p. 824-830.

Research output: Contribution to journalArticle

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