Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists

Alyssa M. Hartung, John A. Beutler, Hernán A. Navarro, David F. Wiemer, Jeffrey D. Neighbors

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The natural stilbene pawhuskin A has been shown to function as an opioid receptor antagonist, with preferential binding to the κ receptor. This finding encouraged assembly of a set of analogues to probe the importance of key structural features. Assays on these compounds determined that one (compound 29) shows potent opioid receptor binding activity and significantly improved selectivity for the κ receptor. These studies begin to illuminate the structural features of these non-nitrogenous opioid receptor antagonists that are required for activity.

Original languageEnglish (US)
Pages (from-to)311-319
Number of pages9
JournalJournal of Natural Products
Volume77
Issue number2
DOIs
StatePublished - Feb 28 2014

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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