STIM and orai proteins as novel targets for cancer therapy. A review in the theme: Cell and molecular processes in cancer metastasis

Ayushi Vashisht, Mohamed Trebak, Rajender K. Motiani

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Calcium (Ca2+) regulates a plethora of cellular functions including hallmarks of cancer development such as cell cycle progression and cellular migration. Receptor-regulated calcium rise in nonexcitable cells occurs through store-dependent as well as store-independent Ca2+ entry pathways. Stromal interaction molecules (STIM) and Orai proteins have been identified as critical constituents of both these Ca2+ influx pathways. STIMs and Orais have emerged as targets for cancer therapeutics as their altered expression and function have been shown to contribute to tumorigenesis. Recent data demonstrate that they play a vital role in development and metastasis of a variety of tumor types including breast, prostate, cervical, colorectal, brain, and skin tumors. In this review, we will retrospect the data supporting a key role for STIM1, STIM2, Orai1, and Orai3 proteins in tumorigenesis and discuss the potential of targeting these proteins for cancer therapy.

Original languageEnglish (US)
Pages (from-to)C457-C469
JournalAmerican Journal of Physiology - Cell Physiology
Volume309
Issue number7
DOIs
StatePublished - Sep 1 2015

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cell Biology

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