STIM1 and Orai1

Novel targets for vascular diseases?

Wei Zhang, Mohamed Trebak

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

The past five years have witnessed the discovery of the endoplasmic reticulum calcium (Ca 2+) sensor STIM1 and the plasma membrane Ca 2+ channel Orai1 as the bona fide molecular components of the store-operated Ca 2+ entry (SOCE) and the Ca 2+ release-activated Ca 2+ current (I CRAC). It has been known for two decades that SOCE and I CRAC are required for lymphocyte activation as evidenced by severe immunodeficient phenotypes in patients lacking I CRAC. In recent years however, studies have uncovered expression of STIM1 and Orai1 proteins in various tissues and described additional roles for these proteins in physiological functions and pathophysiological conditions. Here, we will summarize novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the therapy of vascular disease.

Original languageEnglish (US)
Pages (from-to)780-785
Number of pages6
JournalScience China Life Sciences
Volume54
Issue number8
DOIs
StatePublished - Aug 1 2011

Fingerprint

vascular diseases
Lymphocyte Activation
Vascular Diseases
Endoplasmic Reticulum
Blood Vessels
Cell Membrane
Calcium
Phenotype
protein
Lymphocytes
Cell membranes
lymphocyte proliferation
endoplasmic reticulum
phenotype
Proteins
plasma membrane
proteins
Chemical activation
calcium
Tissue

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

@article{7801290bcb79407db0a71d64cc5c743f,
title = "STIM1 and Orai1: Novel targets for vascular diseases?",
abstract = "The past five years have witnessed the discovery of the endoplasmic reticulum calcium (Ca 2+) sensor STIM1 and the plasma membrane Ca 2+ channel Orai1 as the bona fide molecular components of the store-operated Ca 2+ entry (SOCE) and the Ca 2+ release-activated Ca 2+ current (I CRAC). It has been known for two decades that SOCE and I CRAC are required for lymphocyte activation as evidenced by severe immunodeficient phenotypes in patients lacking I CRAC. In recent years however, studies have uncovered expression of STIM1 and Orai1 proteins in various tissues and described additional roles for these proteins in physiological functions and pathophysiological conditions. Here, we will summarize novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the therapy of vascular disease.",
author = "Wei Zhang and Mohamed Trebak",
year = "2011",
month = "8",
day = "1",
doi = "10.1007/s11427-011-4206-6",
language = "English (US)",
volume = "54",
pages = "780--785",
journal = "Science China Life Sciences",
issn = "1674-7305",
publisher = "Science in China Press",
number = "8",

}

STIM1 and Orai1 : Novel targets for vascular diseases? / Zhang, Wei; Trebak, Mohamed.

In: Science China Life Sciences, Vol. 54, No. 8, 01.08.2011, p. 780-785.

Research output: Contribution to journalReview article

TY - JOUR

T1 - STIM1 and Orai1

T2 - Novel targets for vascular diseases?

AU - Zhang, Wei

AU - Trebak, Mohamed

PY - 2011/8/1

Y1 - 2011/8/1

N2 - The past five years have witnessed the discovery of the endoplasmic reticulum calcium (Ca 2+) sensor STIM1 and the plasma membrane Ca 2+ channel Orai1 as the bona fide molecular components of the store-operated Ca 2+ entry (SOCE) and the Ca 2+ release-activated Ca 2+ current (I CRAC). It has been known for two decades that SOCE and I CRAC are required for lymphocyte activation as evidenced by severe immunodeficient phenotypes in patients lacking I CRAC. In recent years however, studies have uncovered expression of STIM1 and Orai1 proteins in various tissues and described additional roles for these proteins in physiological functions and pathophysiological conditions. Here, we will summarize novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the therapy of vascular disease.

AB - The past five years have witnessed the discovery of the endoplasmic reticulum calcium (Ca 2+) sensor STIM1 and the plasma membrane Ca 2+ channel Orai1 as the bona fide molecular components of the store-operated Ca 2+ entry (SOCE) and the Ca 2+ release-activated Ca 2+ current (I CRAC). It has been known for two decades that SOCE and I CRAC are required for lymphocyte activation as evidenced by severe immunodeficient phenotypes in patients lacking I CRAC. In recent years however, studies have uncovered expression of STIM1 and Orai1 proteins in various tissues and described additional roles for these proteins in physiological functions and pathophysiological conditions. Here, we will summarize novel findings pertaining to the role of STIM1 and Orai1 in the vascular system and discuss their potential use as targets in the therapy of vascular disease.

UR - http://www.scopus.com/inward/record.url?scp=79960648726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960648726&partnerID=8YFLogxK

U2 - 10.1007/s11427-011-4206-6

DO - 10.1007/s11427-011-4206-6

M3 - Review article

VL - 54

SP - 780

EP - 785

JO - Science China Life Sciences

JF - Science China Life Sciences

SN - 1674-7305

IS - 8

ER -