Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins

Anthony E. Pegg, Wayne Perry

Research output: Contribution to journalArticle

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Abstract

An enzymatic activity present in rat liver extracts catalyzes the transfer of methyl groups from O6-methylguanine in DNA to protein. This activity was stimulated by treatment of rats with thioacelamide, carbon tetrachioride, 1,2-dimethylhydrazine, diethylnitrosamine, dimethylnitrosamine and by partial hepatectomy but not by treatment with N-methyl-N-nitrosourea or streptozotocin. These results suggest that an enhancement of this activity accompanies the in crease in cell division brought about by these agents and is not necessarily a specific response to the presence of alkylated bases in DNA.

Original languageEnglish (US)
Pages (from-to)1195-1200
Number of pages6
JournalCarcinogenesis
Volume2
Issue number11
DOIs
StatePublished - Dec 1 1981

All Science Journal Classification (ASJC) codes

  • Cancer Research

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